他们在《Heliyon》期刊上发表了题为 “T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla*91 and STX11 p.R129P mutations” 的论文,试图揭开 BCL11B 和 STX11 杂合突变与疾病之间的神秘面纱23。 研究人员为了深入探索,运用了多种关键技术方法。首先是基因测序技术,...
此外作者还发现siIEL中Bcl11b-/- IFN-γ+TNFα+ CD8+ T显著减少,IFN-γ和TNFα被报道在激活和招募外周记忆细胞和其它免疫细胞中发挥作用,作者发现过继回输Bcl11b-/- OT-I细胞的小鼠与过继回输WT细胞的小鼠相比,siIEL中NK1.1+细胞明显减少。这些结果说明Bcl11b调节记忆性T细胞和记忆前体细胞在脾脏和组织中的...
9月22日,中国科学院广州生物医药与健康研究院李鹏团队和刘兴国团队共同在国际学术期刊EMBO Journal上发表了题为BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells的研究成...
T cells and mature T cells both acquire NK cell properties, transforming them into natural killer (NK) cells upon BCL11B deletion during culture. These reprogrammed cells possess unique properties of proliferation, cytokine dependency and target cell killing [1, 16]. Our data revealed that after ...
cell lines reduces proliferation and resistance to apoptosis, with minimal impact on normal T cells. Furthermore, studies by others have shown that knocking out BCL11B not only does not inhibit immune function but can also induce normal T cells to adopt NK cell-like phenotypes,14which could ...
Bcl11b-deficiency results in a developmental arrest of early T cell progenitors at the DN2a stage along with a concomitant acquisition of myeloid- lineage/natural killer (NK) cell gene signatures5. Bcl11b thus serves as a T-lineage commitment factor that eliminates devel- opmental potential to ...
Bcl11b-deficiency results in a developmental arrest of early T cell progenitors at the DN2a stage along with a concomitant acquisition of myeloid- lineage/natural killer (NK) cell gene signatures5. Bcl11b thus serves as a T-lineage commitment factor that eliminates devel- opmental potential to ...
Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8– double-negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor Bcl11b begins. In vivo and in vitro stage-specific deletions globally
BCL11B and the NuRD complex bind to each other and repress natural killer (NK)‐cell fate in T cells. In addition, T cells upregulate the NK cell‐associated receptors and transcription factors, lyse NK‐cell targets, and are reprogrammed into NK‐like cells (ITNKs) upon deletion of MTA2...
Mechanistically, the Bcl11bN440K mutation dampens the interaction of BCL11B with T cell factor 1 (TCF1) in thymocytes, resulting in weakened antagonism against TCF1 activity that supports the differentiation of NK/ILC1-like cells. Collectively, our results shed new light on the function of BCL...