目的 评价乙型肝炎病毒(HBV)慢性携带小鼠中CD27和CD11b标记自然杀伤(NK)细胞亚群的变化. 方法 将pAAV-HBVl.2质粒采用高压水动力法尾静脉注入C57BL/6小鼠体内,作为造模组,空载质粒作为对照组;检测不同时间点肝功能和病毒学指标判断HBV质粒慢性携带动物模型构建情况;采用流式细胞术检测脾脏和肝脏中NK细胞及CD11b联合...
In conclusion, a substantial proportion of CD11b−CD27−NK subsets among TINK cells accounts for NK-cell dysfunction in patients with HCC and is associated with tumor progression. Our study may provide a novel therapeutic target for the treatment of patients with HCC. 展开 关键词: CD11b CD...
CD27 is expressed on naïve CTL, as well as CD4 + T cells, natural killer (NK) cells and a subset of B cells, and expression of its one known ligand, CD70 can be induced on dendritic cells by the combined stimulation ways (via CD40)12–15. Soefvienrfallamlinmesatoofrye1v2...
This is in contrast with the resembling mice cells called "age-associated B cells" ( CD11c+CD11b+Tbet+ cells) that were originally described in the spleen of aged female m ice39. Our study showed that the critical expansion of C D21−CD27− B cells is specific to SLE ...
既往研究表明CD200可能通过增强骨髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)的功能促进肿瘤生长。例如,BELKIN等在CSCC小鼠模型研究中发现CD200通过调节MDSC的功能来抑制抗肿瘤免疫反应,促进转移性CSCC细胞的存活及转移瘤形成。同样,CHOUERIRY等发现CD200在人胰腺...
一说到癌症,给人的感觉就是恐惧、绝望。医学界曾有资料称癌症患者有1/3是被吓死的。其实癌症并非我们想象的那么可怕,早发现,早治疗,完全治愈或帯瘤生存的机会还是有的。所以不是所有的癌症都是致命的,以下几种癌症的生存率还是很高的。接下来小编带大家看看十大不致命...
NK cells are a major component of the antitumour immune response that limits tumour progression. However, it has been reported that tumour-infiltrating NK (TINK) cells from patients with non-small-cell lung carcinoma (NSCLC) exhibit profound defects in degranulation and IFN-γ production. In supp...
CD11b 和 CD27 定义人类 NK 细胞新亚群的 研究进展doi:10.3969/j.issn.1002-266X.2020.19.029杨梅刘勇Shandong Medical Journal
CD11bCD27自然杀伤细胞(NK)是固有免疫的重要组成部分,无需抗原预先致敏,即可直接杀伤肿瘤,病毒或细菌感染的靶细胞,是机体免疫防御的第一道防线.人类NK细胞既往根据CD56抗原表达划分为CD56 dim,CD56 bright亚群,我国研究学者发现CD11b和CD27定义的人类NK细胞亚群,可将NK细胞划分为四个功能精细,迥异的亚群,即CD11b-CD...
In this study we report on the identification and induction of memory-like NK cells by a combination of a lipid nanoparticle (LNP) loaded with a stimulator of interferon genes (STING) agonist (STING-LNP) and CpG-ODN, and the potential of memory-like NK cells against melanoma lung metastasis...