设什、"≈l删K*畅、U”5【()I⋯lCD11b 和 CD27 定义人类 NK 细胞新亚群的研究进展杨梅,刘勇中国医科大学附属盛京医院,沈阳 110004 摘要:自然杀伤细胞(NK)是固有免疫的重要组成部分,无需抗原预先致敏,即可直接杀伤肿瘤、病毒或细菌感染的靶细胞,是机体免疫防御的第一道防线。 人类 NK 细胞既往根据 CD56 ...
Interestingly, we found a substantial CD11bCD27 (DN) NK-cell population harboured within the tumour tissues. The presence of this CD11bCD27 NK subset indicated that the TINK cells were of an immature and inactive phenotype. Remarkably, we determined that the presence...
自然杀伤细胞(Natural killer cells,NK cells)是天然免疫系统的重要成员,分布于外周各淋巴器官及血液循环系统。为了进行NK细胞发育方面的研究,我们选取三种人NK细胞:外周血NK细胞、脐血NK细胞和蜕膜NK细胞进行分析。研究结果表明采用CD11b和CD27表面分子可以将人NK细胞划分为四个不同阶段。几乎所有的外周血NK细胞都是CD...
CD11bCD27dysfunctionNKsubsetsNatural killer(NK)cells have a vital role in killing hepatocellular carcinoma(HCC)cells;however,the mechanism underlying tumor-infiltrating NK(TINK)-cell dysfunction remains poorly understood.Using flow cytometry staining,we precisely characterized the frequency,phenotype and funct...
(non-small cell lung carcinoma, NSCLC)病人体内的肿瘤浸润NK细胞(tumor-infiltrating NK cells, TINK cells)的杀伤功能和分泌IFN-Y能力严重缺失,并证明与TINK细胞表面各种受体的表达变化相关,而TINK细胞表面受体的表达变化是由于肿瘤细胞表面与之对应的配体表达发生变化所致,由此说明可能是肿瘤微环境造成了TINK细胞的...
adipose tissue Th2 cells resident memory ST2 ILC2 PD-1 receptor Research topic(s) CP: Immunology CP: Metabolism Introduction The adipose tissue is infiltrated by a variety of immune subsets that regulate its metabolic functions and local responses to perturbations. In the visceral adipose tissue (...
CD27 is expressed on naïve CTL, as well as CD4 + T cells, natural killer (NK) cells and a subset of B cells, and expression of its one known ligand, CD70 can be induced on dendritic cells by the combined stimulation ways (via CD40)12–15. Soefvienrfallamlinmesatoofrye1v2...
CD27/CD11b界定人NK细胞亚群及其在肿瘤和妊娠中的功能 自然杀伤细胞(Natural killer cells,NK cells)是天然免疫系统的重要成员,分布于外周各淋巴器官及血液循环系统。为了进行NK细胞发育方面的研究,我们选取三种人NK细胞:... 傅斌清,金晶,孙汭,... - 全国免疫学学术大会 被引量: 0发表: 2014年 加载更多来源...
The CD27–CD70 receptor/ligand pair is of interest in this regard, as members of the TNF-receptor superfamily (TNFSF) have been shown to control growth and survival of T cells11. CD27 is expressed on naïve CTL, as well as CD4+ T cells, natural killer (NK) cells and a...
In conclusion, a substantial proportion of CD11b−CD27−NK subsets among TINK cells accounts for NK-cell dysfunction in patients with HCC and is associated with tumor progression. Our study may provide a novel therapeutic target for the treatment of patients with HCC. 展开 关键词: CD11b CD...