bcl/abl融合基因是慢性粒细胞白血病发生发展的重要因素。 具体来说,慢性粒细胞白血病(CML)是一种发生在多能造血干细胞的恶性骨髓增殖性肿瘤,其发病与bcl/abl融合基因密切相关。这种融合基因是由于染色体变异形成的,通常涉及到9号和22号染色体的易位,导致bcl-2基因和abl基因的部分序列融合在一起,形成一个新的具有异常...
Inhibitors of the BCR–ABL1 fusion protein have improved outcomes in Philadelphia-chromosome-positive (Ph+) leukaemias, but acquired resistance can limit drug responses. Now, axitinib, a VEGFR inhibitor approved for second-line therapy of renal cell carcinoma, has been identified as an inhibitor of...
问题描述: (女,43岁) 急性淋巴细胞白血症(BCL_ABL P210阳性 )治愈率多高, 医生回答 问题分析:病人家属咨询:急性淋巴细胞白血症(BCL_ABLP210阳性)治愈率多高。家属未提供病历资料。 指导建议:这个要根据病人具体情况,特别是病人两个疗程化疗后,是否取得骨髓完全缓解,以及后续治疗是否规范到位。谢谢。 咨询过程 病...
There was no difference in tumor latency in young mice infected; however, following ABL-MYC infection, aged Bcl-X L mice demonstrated a median survival of 9 weeks, while littermate control mice demonstrated a median survival of 19 weeks. Interestingly, while both littermate control and Bcl-X ...
Dasatinib(达沙替尼)是非受体酪氨酸激酶 Abl 和 Src 以及 Src 家族其他成员的有效抑制剂。 它在亚纳摩尔浓度下有效,抑制 Src、Abl 和 Lck,IC50 值分别为 0.05、0.5 和 0.4 nM。在纳摩尔浓度下,达沙替尼还阻断其他几种受体和非受体酪氨酸激酶的活性, 加上耐药突变体。 由于这些活性,达沙替尼对以这些激酶水平...
“By coupling the FIMM findings with Pfizer's deep oncology and structure-based drug discovery expertise, we were able to define the unique mechanism by which axitinib binds to the drug-resistant version of BCR–ABL1, and this information could aid the rational design of next-generation ABL1 ...
The GLG1 protein is a transmembrane protein known also as MG-160, ESL-1, and CFR-1. Irregularities in the GLG1 functions affect the adhesion, mobility, and migration of cells. In this study, the interaction between the GLG1 protein and the Bcr-Abl oncoprotein is shown for the first ...
Leo E, Mancini M, Aluigi M, Castagnetti F, Martinelli G, Barbieri E and Santucci MA: DNA hypermethylation promotes the low expression of pro‑apoptotic BCL2L11 associated with BCR‑ABL1 fusion gene of chronic myeloid leukaemia. Br J Haematol 159: 373‑376, ...
(2012) DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR-ABL1 fusion gene of chronic myeloid leukaemia. Br J Haematol 159: 373-376.Leo E, Mancini M, Aluigi M, et al. DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 ...