[6] Alam M, Alam S, Shamsi A, Adnan M, et al. Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer. Front Oncol. 2022 Mar 25;12:869672. 更多推荐:
B 细胞淋巴瘤-2 （BCL2） 最初被发现是一种在滤泡性淋巴瘤中过表达的癌蛋白。后来发现 BCL2 通过...
Bcl-2蛋白家族是细胞凋亡(也叫程序性细胞死亡)的核心调节机制之一,可以接收和传递内在胞内信号或外部环境应激信号,如营养或缺氧胁迫、DNA损伤、致癌基因过量激活、内质网应激胁迫等,主要在内在凋亡途径(Intrinsic pathway)中起主导作用。 ...
Intrinsic pathway又称线粒体凋亡通路,是已Bcl2蛋白家族为调节核心的凋亡调节通路。根据功能和Bcl2 homology (BH) domains的组成,Bcl-2家族蛋白可分为三类。第一类:抗凋亡Bcl2蛋白,含结构域BH1、BH2、BH3、BH4,如Bcl-2、Bcl xl,通过与促凋亡成分直接作用抑制细胞凋亡。第二类:促凋亡蛋白Bax和Bak,含结构域BH1...
[9] Métrailler-Ruchonnet I, Pagano A, Carnesecchi S, Ody C, Donati Y, Barazzone Argiroffo C. Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway. Free Radic Biol Med. 2007 Apr 1;42(7):1062-74.. ...
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathwaySYSTEMIC lupus erythematosusT cellsBCL-2 proteinsCELL differentiationAUTOIMMUNE diseasesSystemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, ...
将CLPB缺失后的细胞进行RNA Sequence测序,KEGG通路富集分析发现缺失后基因改变主要集中在氨基酸代谢途径和碳代谢,和CLPB在调控线粒体功能相一致。Ingenuity Pathway Analysis寻找上游转录因子改变,发现ATF4列第一位,ATF4已被确定为哺乳动物线粒体应激反应的关键调节因子,因此判...
implying Bcl-2's role lies in regulating sites downstream of apoptosis pathway modulation.Bcl-2's anti-apoptotic effects might relate to several mechanisms:1. Antioxidant function: Overexpression of Bcl-2 reduces the production of reactive oxygen species (ROS) and lipid peroxidation, indi...
人Human BCL2靶点分子功能(预测) Enables several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of apoptotic process; and positive regulation of...
Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-/c-induction pathway mediated by family protein-tyrosine kinases and the induction pathway. Here, we provide evidence for the existence of a third, -sensitive pathway, which results in the induction of ...