高糖介导人牙周膜细胞凋亡中bcl-2,bax的作用及机制(英文)High glucose can trigger apoptosis in human periodontal ligament cells, which is a complex process.Bcl - 2 is an anti - apoptotic protein that plays a crucial role in this context.The expression level of Bcl - 2 is often altered in ...
This process is fundamental for the proper maturation of functional neuronal networks and requires strict regulation via different pathways [1–3]. Key players in the apoptotic process are members of the B-cell lymphoma 2 (BCL-2) family [4, 5]. This protein family has up to four BCL-2 ...
P53 protein expression was upregulated while cells were arrested at the G2/M phase of the cell cycle. There was a decrease in the expression of anti-apoptotic Bcl-2 and Bcl-xL proteins, whereas pro-apoptotic Bax was increased. The two classical caspase substrates, PARP and ICAD, were both...
Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated ...
探讨丙酸睾酮在大鼠胸腺退化过程中的作用及其对大鼠胸腺中Bcl一2和Bax表达的影响。方法 雄性大鼠去势后给予丙酸睾酮皮下注射,分别于注射后第1、4、7天取材,用半薄切片甲苯胺蓝染色检测胸腺细胞凋 亡情况,免疫组织化学法检测胸腺组织中Bcl一2和Bax的表达情况,采用t检验进行统计学处理。结果 ...
The Bcl-2–associated X protein (Bax), is a protein of the Bcl-2 family. It promotes apoptosis by competing with Bcl-2. The expression ofBAXis upregulated by p53 andBaxhas been shown to be involved in p53-mediated apoptosis. TheBaxgene has also been implicated in lupusnephritis[78]. De...
观察艾塞那肽(EX)对糖尿病(DM)大鼠心肌组织Bcl-2、Bax表达的影响。方法 高糖高脂饲料 喂养联合尾静脉注射小剂量链脲佐菌素建立DM大鼠模型20只,随机分为DM组、EX组,EX组皮下注射EX1.0 nmoL/(kg·d),设正常对照10只(N组)。12周后,应用实时定量PCR、Westernblot法检测大鼠心肌组织中的Bc1. ...
Bax Rabbit Monoclonal Antibody(Bax兔单克隆抗体)是将Bax作为抗原对兔进行免疫后筛选出只产生的Bax抗体的B淋巴细胞,再将B细胞通过细胞融合技术与骨髓瘤杂交然后筛选出只分泌Bax抗体的杂交瘤细胞,最后通过层析柱纯化制的高纯度的Bax抗体兔单克隆抗体。Bax(Bcl-2 associa
Geju Hugan Tablets Ameliorate Alcohol-induced Liver Injury in Mice by Regulating NF-κB and Bcl-2/Bax Signaling Pathways 引用 收藏 分享 摘要 目的:探究葛菊护肝片对酒精性肝损伤小鼠肝脏的保护作用,并基于核转录因子-κB p65(NF-κB p65)和B细胞淋巴瘤-2(Bcl-2)蛋白/Bcl-2相关X蛋白(Bax)信号通路...
亚低温各组Bcl-2表达阳性细胞数均明显多于常温组,说明亚低温治疗使Bcl-2 表达上调而抑制凋亡。Bcl-2和Bax蛋白含量的比值决定细胞凋亡过程的发生,凋亡的神经元会同时出现Bax表达升高和Bcl-2表达降低[16,17],随着缺血时间的延长如果没有新的刺激因素作用,Bcl-2表达降低,Bcl-2阳性细胞数减少。有实验发现亚低温治疗12...