Full size table BCL-X The BCL-X or BCL2L1 (BCL2-like 1) gene has 44% homology to BCL-2. It has two well-known isoforms, BCL-XL and BCL-XS (Table 2), as well as a number of other characterised isoforms16,17. The two major isoforms arise from alternative splicing of BCL-X; ...
Bcl2样蛋白11(BCL2L11)重组蛋白 种属: Homo sapiens (Human) 蛋白长度: Full Length 来源: E.coli 分子量: 26.2 kDa 表达区域: 1-198aa 氨基酸序列 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQ
Sign in to download full-size image Fig. 2.Bcl-2 family members display significant structural homology despite limited sequence similarity. Shown are ribbon diagrams of Bcl-2 proteins(a)Bax[24];(b)Bid[25,26];(c)KSHV Bcl-2[30••];(d)Bcl-2[28••]; and(e)Bcl-XL[27...
Full size image Viral–host TMD–TMD interactions are necessary to modulate apoptosis To identify whether these newly found viral–host TMD–TMD interactions are necessary to control cellular apoptosis, we transfected HeLa cells with Bcl2, HHV8, or MyxV either with or without the TMD (FL and Δ...
Miyamoto Y, Hosotani R, Wada M, Lee JU, Koshiba T, Fujimoto K, Tsuji S, Nakajima S, Doi R, Kato M, et al .: Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers. Oncology 1999, 56 : 73-82. PubMed Abstract Publisher Full Text...
兔抗bcl2l2多克隆抗体 宿主:rabbit 抗原:bcl2l2 反应种属:human, mouse 标记物:unconjugate 克隆类型:rabbit polyclonal 技术规格 background: this gene encodes a member of the bcl-2 protein family. the proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic ...
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Thus, the naturally occurring Bok-S variant represents a new form of proapoptotic protein that induces cell killing without heterodimerization with antiapoptotic Bcl-2 proteins. This variant appears to contain the minimal module spanning BH1 and BH2 domains and the transmembrane sequence for apoptosis...
最近发现Bcl-2分子通过与其 他促凋亡分子相互作用调控线粒体外膜通透性,其具体分子机制尚不完全清楚。本课题组采用化学生物学 方法,在研究Bax/Bak非依赖的细胞凋亡途径中,发现了一些小分子化合物能够诱导Bim表达量急剧升高, Bim能转位到线粒体上,与Bcl-2相互作用增强,并直接促进Bcl-2构象变化。有意义的是,Bim可以...
Full size image Given the known impact of ABT263 on the levels of Bcl-2 family members, we evaluated the expression of Bcl-2, Bcl-xL and Mcl-1 upon ABT263, Selinexor and Selinexor +ABT263 treatment. While ABT263 up-regulated Mcl-1 protein levels, this increase was attenuated in the presen...