Basic Amino Acid Residues in the V3 Loop of Simian Immunodeficiency Virus Envelope Alter Viral Coreceptor Tropism and Infectivity but Do Not Allow Efficient Utilization of CXCR4 as Entry CofactorFIG. 2. Detection of viral proteins in 293T cells transfected with proviral SIVmac239 constructs ...
The results clearly indicate that the basic amino acid residues in the β-region of AtxA contribute to, but are not necessary for, its neurotoxic effect. 展开 关键词: Enzymatic activity Phospholipase A 2 Neurotoxicity Receptor-binding affinity Site-directed mutagenesis Vipera ammodytes ammodytes ...
These results, when taken together, suggest that basic amino acid residues in the common homeodomain of EGAM1 and EGAM1C and the intact structures of the EGAM1 homeoproteins contribute, at least in part, to the nuclear localization of these proteins in mouse ES cells....
RESULTS: A region corresponding to the C terminus of the X domain and the XY-linker, which contains clusters of basic amino acid residues, was essential for the nuclear import of PLCdelta1 in Madin-Darby canine kidney cells. A series of point mutations on lysine residues in this region ...
Roles of conserved basic amino acid residues and activation mechanism of the hyperthermophilic aspartate racemase at high temperature. X-ray crystallography has revealed two similar alpha/beta domains of the aspartate racemase from the hyperthermophilic archaeon, Pyrococcus horikoshii OT3... Yoshida TSeko...
These results, when taken together, suggest that basic amino acid residues in the common homeodomain of EGAM1 and EGAM1C and the intact structures of the EGAM1 homeoproteins contribute, at least in part, to the nuclear localization of these proteins in mouse ES cells. 展开 关键词: Crxos1 ...
aThe major molecular determinant of pathogenicity is the presence of multiple basic amino acids at the proteolytic cleavage site of HA rendering it cleavable by ubiquitous furin proteases present in many tissues, whereas LPAIVs carry only two non-consecutive basic amino acid residues at the same po...
In the previous studies [21, 22], it was proposed that specific basic amino acid residues on the surface of IpTxa are required for the electrostatic interaction of the toxin with RyR1. Particularly, Gurrola et al. [15] suggested the structural domain composed of Lys19-Arg24 followed by Thr...
Taking into account the high extend of basic amino acid residues (arginine, lysine, and histidine residues) on the surface of these proteins, we could explain this outcome by a lesser number of arginine residues that could bind ANS in the sample from the H-group, fol...
These results, when taken together, suggest that basic amino acid residues in the common homeodomain of \{EGAM1\} and \{EGAM1C\} and the intact structures of the \{EGAM1\} homeoproteins contribute, at least in part, to the nuclear localization of these proteins in mouse \{ES\} cells....