One of hot research foci has always been predicting amino acid residues underlying functional divergence after gene duplication, as those predicted sites can be used as candidates for further functional experimentations. It is important and interesting to know how many sites, on average, may have ...
Although the unfolding and refolding of proteins have been extensively studied in the literature, relatively few attempts have been made to see how many residues of the total residues of a certain amino acid in an enzyme can be modified without seriously affecting its folding. Based on a statisti...
It has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues that are directly involved in protein function. In agreement with this hypothesis, recent work has shown a negative correlat
are used as medical tracers and in thyroid disease diagnosis and therapy. Iodine compounds are used as germicides, antiseptics, and dyes. Atomic number 53; atomic weight 126.9045; melting point 113.7°C; boiling point 184.4°C; density of gas 11.27 grams per liter; specific gravity (solid, at...
(Supplementary Fig.1). We split the dataset into 80% training data and 20% test data in such a way that enzymes with the same amino acid sequence would not occur both in the training and in the test set. This splitting procedure does not prevent the inclusion of enzymes in the test ...
A recent genetic association study has identified a microsatellite in the coding sequence of the asporin gene as a susceptibility factor for osteoarthritis (OA). Alleles of this microsatellite determine the variable number of aspartic acid residues in the amino-terminal end of the asporin protein....
Of the 14 unique mutated amino acid residues within RepA that we identified in our screen, only one has been rigorously characterized– E9310. Petersonet al. showed that an E93K mutation yielded a copy number of ~30 copies/cell, while an E93R mutation resulted in a copy number of ~240 ...
terrestris (Bter) corazonin preprohormone, first the signal peptide (underlined) is removed by a signal peptidase, after which the corazonin sequence (highlighted in yellow) is excised by a prohormone convertase (PC 1/3), cleaving at the C-terminal side of pairs of bas...
After reaching full substitution of all acidic hydrogens for sodium ions, further increases in the concentration of sodium cations do not lead to the attachment of additional sodium atoms. This effect allows counting of acid residues in a peptide. This information is easily acquired and may be ...
Analysis of Emr1 amino acid sequences with the online bioinformatics tool TMHMM 2.0 (http://www.cbs.dtu.dk/services/TMHMM/)28predicted that Emr1 is a transmembrane protein carrying a transmembrane domain consisting of 23 amino acid residues (a.a., 21–43) in the middle and that N-terminal...