Key amino acid residues (RF, DQ motifs, residues for nucleophilic elbow, catalytic triads, N-terminal conserved Cys for disulfide bond and oxyanion hole) of 39 carboxylesterases deduced from Loc...
Svedendahl Humble M, Cassimjee KE, Abedi V, Federsel H, Berglund P (2012) Key Amino Acid Residues for Reversed or Improved Enantiospecificity of an ω-Transaminase . ChemCatChem 4 : 1167–1172HUMBLE M S; CASSIMJEE K E; ABEDI V;.Key amino acid residues for reversed or improved en- ...
(2002) Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase. Plant J. 31: pp. 555-564Sawada, Y.; Kinoshita, K.; Akashi, T.; Aoki, T.; Ayabe, S.: Key amino acid residues required for aryl migration catalysed by the ...
Studies on the key amino acid residues responsible for the alkali-tolerance of the xylanase by site-directed or random mutagenesis. J Mol Catal B: Enzym 2002;18:307-13.Liu, X., Qu, Y., You, F., and Liu, Y., Studies on the key amino acid residues responsible for the alkali-...
Recently, we found that a neoculin variant in which all five histidine residues are replaced with alanine elicits intense sweetness at both neutral and acidic pH but has no taste-modifying activity. To identify the critical histidine residue(s) responsible for this activity, we produced a series...
Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies. The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce ...
Here, we comprehensively screened key amino acid residues of NCL using nuclear magnetic resonance (NMR) spectroscopy and alanine scanning mutagenesis. We found that the mutations of Arg48, Tyr65, Val72 and Phe94 of NCL basic subunit increased or decreased both the antagonist and agonist activities...
Further study showed that M1 was implicated more than M2 for viral growth and pathogenicity in vitro and in vivo , and the key amino acid residues of M1-41V and M2-27A were responsible for these characteristics in cells and in mice. These key residues of M1 and M2 proteins could be ...
Sequence analysis suggests that the number of amino acid residues in most mitochondrial cyts- c is in the range 104 卤 10, and amino acid residues at only few positions are highly conserved throughout evolution. These highly conserved residues are Cys14, Cys17, His18, Gly29, Pro30, Gly41...
Amino acid residues 33-44 of the common alpha-subunit of the glycoprotein hormones have been implicated in heterodimerization as well as high affinity rece... M Grossmann,MW Szkudlinski,JA Dias,... - 《Molecular Endocrinology》 被引量: 67发表: 1996年 Amino acid and glucose metabolism in fed...