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不要忽略了lc3-2除了通过溶酶体降解以外还可以通过裂解PE重新变回LC3-1
产品名称:Bafilomycin A1CAS:88899-55-2产品介绍:Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces...
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摘要: Examines the synthesis of bafilomycin A, an enantiomer of adenosine triphosphatase inhibitor. Aldol reaction between methyl ketone and aldehyde; Macrocyclization of the seco ester precursor; Stereochemistry of the aldol.被引量: 26 年份: 2002 ...
United States Patent US7214705 Note: If you have problems viewing the PDF, please make sure you have the latest version ofAdobe Acrobat. Back to full text
OPMA00072 was found to produce inhibitors of the synthesis of neutral lipids in a cell-based assay using Chinese hamster ovary (CHO) cells. A new 16-membered macrolide named bafilomycin L (BFL) (1) was isolated along with the known structurally related bafilomycin C1 (BFC1) (3) from the ...
The involvement of intracellular acidic vesicles in the early phase of Japanese encephalitis (JE) virus infection in Vero cells was observed by adding a specific vacuolar type H+ -ATPase (V-ATPase) inhibitor (bafilomycin A1) in the cell culture medium. Studies with the detection of viral envelop...
Cell-type and Amyloid Precursor Protein-type Specific Inhibition of A? Release by Bafilomycin A1, a Selective Inhibitor of Vacuolar ATPases (1995) Cell-type and amyloid precursor protein-type specific inhibition of Aβ release by bafilomycin A1, a selective inhibitor of vacuolar ATPases. J......
Of the functional mutants, three displayed Ki values for bafilomycin significantly different from wild-type (0.22 ± 0.03 nm). These included E721K (Ki 0.38 ± 0.03 nm), L724A (0.40 ± 0.02 nm), and N725F (0.54 ± 0.06 nm). Only the N725F mutation displayed a Ki for concanamycin (...