Bafilomycin A1,中文名巴佛洛霉素 A1 或巴菲霉素 A1 ,简称 Baf A1 ,大环内酯类抗生素,是特异性、可逆的 V-ATPase 抑制剂,也是一种 自噬(autophagy)晚期阶段抑制剂。它能够阻断自噬体与溶酶体的融合,并抑制细胞溶酶体中的酸化和蛋白质降解。 01 作用机制 Bafilomycin A1 可以破坏自噬体-溶酶体融合和自溶酶体酸化...
Bafilomycin A1 at a low concentration (1 nM) effectively and specifically inhibits and kills pediatric B-cell acute lymphoblastic leukemia cells. It targets both early and late stages of the autophagy pathway, mitochondria and induces caspase-independent apoptosis. Bafilomycin A1 induces the binding of...
Autophagy is the homeostatic degradation and recycling of macronutrients and organelles mediated by their targeted delivery to lysosomes. Autophagic stress occurs with nutrient deprivation or lysosome dysfunction and if left unchecked can lead to both caspase-dependent and -independent cell death. We have...
AutophagyParasiteSARS-CoVTLR ¥ 136 现货 规格 数量 客户已引用 "Bafilomycin A1"的相关化合物库 大环化合物库 Macrocyclic Compound Library L9300210 化合物 产品详情 NO PAINS 化合物库 NO PAINS Compound Library L40209384 化合物 产品详情 微生物天然产物库 ...
Bafilomycin A1 品牌:MedChemExpress (MCE) Drug_Names:巴佛洛霉素A1;巴弗洛霉素A1 Catalog_No:HY-100558 CAS:88899-55-2 产品活性:Bafilomycin A1 (BafA1) 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为4-400 nmol/mg。Bafilomycin A1,大环内酯类抗生素, 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin ...
产品名称:Bafilomycin A1CAS:88899-55-2产品介绍:Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces...
Carvedilol是一种自噬(autophagy)诱导剂,可抑制NLRP3炎性体。蛋白酶抑制剂Cocktail(mini片剂)可以用于细胞或组织提取物用来增加蛋白稳定性。Wortmannin(SL-2052)是一种有效的,不可逆的,选择性PI3K抑制剂,IC50值为3nM。Wortmannin(SL-2052)阻断自噬(autophagy)形成,并有效抑制Polo-likekinase1(PlK1)和Plk3,IC50值分别...
(V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca²⁺-ATPases, Na⁺/K⁺-ATPases and plasma membrane H⁺-ATPases. Also prevents autophagy at ...
Bafilomycin A1巴佛洛霉素A1;Vacuolar H+ ATPase (V-ATPase)液泡型ATP合成酶;Endosomal Acidification Inhibitor胞内体酸化抑制剂;Autophagy Inhibitor自吞噬;CAS NO:88899-55-2; 产品信息 产品名称 产品编号 CAS NO. 规格 价格(元) Bafilomycin A1巴佛洛霉素A1 ...
Bafilomycin A1 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为 4-400 nmol/mg。 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 阻断自噬体与溶酶体的融合,并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 也诱导调亡 (apoptosis)。