Bafilomycin A1 Bafilomycin A1,中文名巴佛洛霉素 A1 或巴菲霉素 A1 ,简称 Baf A1 ,大环内酯类抗生素,是特异性、可逆的 V-ATPase 抑制剂,也是一种自噬(autophagy)晚期阶段抑制剂。它能够阻断自噬体与溶酶体的融合,并抑制细胞溶酶体中的酸化和蛋白质降解。 01 作用机制 Bafilomycin A1可以破坏自噬体-溶酶体融合和...
Bafilomycin A1 巴佛洛霉素A1 (BafA1) 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为 4-400 nmol/mg。Bafilomycin A1 巴佛洛霉素A1,大环内酯类抗生素, 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 巴佛洛霉素A1 阻断自噬体与溶酶体的融合,并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 巴...
英文名称BAFILOMYCIN A1 autophagy inhibitor, proton pump inhibitor 英文同义词 CAS号 分子式 分子量0 EINECS号 相关类别 Mol文件Mol File 结构式 BAFILOMYCIN A1 自噬抑制剂, 质子泵抑制剂 性质 BAFILOMYCIN A1 自噬抑制剂, 质子泵抑制剂 用途与合成方法 ...
Bafilomycin A1 at a low concentration (1 nM) effectively and specifically inhibits and kills pediatric B-cell acute lymphoblastic leukemia cells. It targets both early and late stages of the autophagy pathway, mitochondria and induces caspase-independent apoptosis. Bafilomycin A1 induces the binding of...
AUTOPHAGYLYSOSOMESCELL deathNEURAL physiologyCHLOROQUINEANTIBIOTICSCALPAINTHERAPEUTICSAutophagy is the homeostatic degradation and recycling of macronutrients and organelles mediated by their targeted delivery to lysosomes. Autophagic stress occurs with nutrient deprivation or lysosome dysfunction and if left unchecked...
Fig. 3. Chemical structures of pharmaceutical drugs derivatives able modulate autophagy in periodontal diseases (A) Rapamycin. (B) Statins [Simvastatin] (C) Bafilomycin A (D) Metformin. Rapamycin, also known as sirolimus, is a non-antibiotic macrolide that exhibits high immunosuppressive and antiprol...
Bafilomycin A1 巴佛洛霉素A1;Vacuolar H+ ATPase (V-ATPase) 液泡型ATP合成酶;Endosomal Acidification Inhibitor 胞内体酸化抑制剂;Autophagy Inhibitor 自吞噬;CAS NO:88899-55-2; 巴佛洛霉素A1(Bafilomycin A1),也称为NSC 381866,来源于灰色链霉菌(Streptomyces griseus)的一种大环内酯类抗生素。巴佛洛霉素A1是一...
Bafilomycin A1,中文名巴佛洛霉素 A1 或巴菲霉素 A1 ,简称 Baf A1 ,大环内酯类抗生素,是特异性、可逆的 V-ATPase 抑制剂,也是一种 自噬(autophagy)晚期阶段抑制剂。它能够阻断自噬体与溶酶体的融合,并抑制细胞溶酶体中的酸化和蛋白质降解。 关键词
Bafilomycin A1 ((-)-Bafilomycin A1) is a specific inhibitor of vacuolar H+-ATPase (V-ATPase) with I50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhi
。[2][1]Autophagy. 2015;11(8):1437-1438.[2]Exp Ther Med. 2015 Nov;10(5):1829-1834.