BAFILOMYCIN A1 1.2 Synonyms (-)-bafilomycin A1 (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5 (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4...
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 规格价格库存数量 1 mg¥ 2,350现货 5 mg¥ 5,370现货 ...
Bafilomycin A1Bafilomycin A1 的详细介绍 Prev Next Bafilomycin A1 $92.00 In stock Qty: Add to Basket Product code: A010-502 Unit Size: 100µg Description Data SheetHighly potent, selective inhibitor of vacuolar type H+-ATPase (V-ATPase). Selective for V-ATPase over other ATP ...
Bafilomycin A1, Baf-A1 中文名称(Chinese Name) 巴佛洛霉素A1 靶点(Target) V-ATPases 通路(Pathway) Membrane Transporter/Ion Channel--Proton Pump CAS号(CAS NO.) 88899-55-2 分子式(Formula) C35H58O9 分子量(Molecular Weight) 622.83 外观(Appearance) ...
Bafilomycin A1 (Baf-A1),又称巴佛洛霉素A1,是从灰色链霉菌分离的大环内酯类抗生素,是可逆的V-ATPases选择性抑制剂,能诱导细胞凋亡,还能通过抑制H+-ATP酶,阻止突触囊泡的重复酸化,抑制自噬体与溶酶体的融合,从而抑制晚期自噬。 产品介绍 Bafilomycin A1 (Baf-A1),又称巴佛洛霉素A1,是从灰色链霉菌分离的大环...
Dose-dependent V-ATPase inhibition with Bafilomycin A1 Back to the top Specifications Working Concentration:0.1 - 1 μM CAS number:88899-55-2 Solubility:0.1 mg/ml in DMSO or ethanol Molecular weight:622.83 g/mol Quality control: Purity: ≥90% (HPLC) ...
Bafilomycin A1(Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is found to inhibit autophagy while induces apoptosis.
Note that inhibition of lysosomal function bybafilomycin A1induces colocalization of TfR with Lamp-1 (Matsui et al., 2011), indicating that TfR is constitutively degraded inlysosomes. View chapterExplore book Molecular Characterization of Autophagic Responses, Part B ...
The increase in FAAs was accompanied by the loss of certain high-molecular-weight yolk proteins and the generation of many smaller peptides. Oocytes stimulated to undergo maturation in the presence of bafilomycin A1, a specific inhibitor of the vacuolar ATPase-dependent proton pump, clarified and ...
However, in the presence of BFL or BFA1, the orange fluorescence was dose-dependently faint, indicating that both com- pounds inhibited V-ATPase in HeLa cells. Next, the direct effect of BFL on V-ATPase activity was tested. ATPase activity in membrane fractions prepared from Saccharomyces ...