330 Deficiency of Bach2 results in improved tumor immunity by enhancing effector function in CD8 T cellsdoi:10.1016/j.jid.2017.07.525Y. SatoM. Matsui-WatanabeM. MatsumotoD.R. ShardaK. IgarashiR. OkuyamaJournal of Investigative Dermatology
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med 2013; 19: 1014–1022. 40 Msaki A, Sanchez AM, Koh LF, Barre B, Rocha S, Perkins ND et al. The role of RelA (p65) threonine 505 phosphorylation in the regulation of ...
et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat. Med. 19, 1014–1022 (2013). CAS PubMed PubMed Central Google Scholar Roychoudhuri, R. et al. BACH2 represses effector programs to stabilize Treg-mediated immune ...
Here, we found that Ikaros, a tumor suppressor encoded by IKZF1, directly binds to both the BCL6 and BACH2 promoters where it suppresses BCL6 and promotes BACH2 expression in B-cell ALL (B-ALL) cells. Casein kinase 2 (CK2) inhibitors increase Ikaros function thereby inhibiting BCL6 and...
展开 关键词: Cell Line, Tumor Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 20 Humans Burkitt Lymphoma Translocation, Genetic Oncogene Proteins, Fusion Basic-Leucine Zipper Transcription Factors bcl-X Protein DOI: 10.1002/gcc.20863 被引量: 22 年份...
Tumor necrosis factor-alpha (TNF-α) has been shown to cause apoptosis of gingival epithelial cells (GECs) in periodontitis. However, the underlying molecular mechanism is still unclear. In this study, we showed that miR-142 expression was significantly elevated in human GECs after exposure to TN...
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint Nat. Med., 19 (2013), pp. 1014-1022 CrossrefView in ScopusGoogle Scholar Tanaka et al., 2016 H. Tanaka, A. Muto, H. Shima, Y. Katoh, N. Sax, S. Tajima, A. Brydun, T. ...
BACH2 exerts multifaceted effects in tumor immunosuppression and cancer pathogenesis, influencing diverse aspects of immune cell function and tumor biology. Its complicated regulatory functions in both innate and adaptive immune responses underscore its potential as a therapeutic target for enhancing antitumor...
结果:肝癌组织中BACH1高表达,BACH1水平升高与肝癌患者肿瘤数量增加,包膜丢失,微血管浸润,分化较差,原发灶-淋巴结-远处转移(Tumor Node Metastasis,TNM)分期不良有关.过表达BACH1增加肝癌侵袭和转移,敲减BACH1抑制肝癌侵袭和转移.BACH1调控细胞运动相关基因的表达,尤其是IGF1R和PTK2.BACH1直接结合到IGF1R和PTK2基因...
近日,瑞典卡罗林斯卡学院、中国郑州大学、北京大学的研究人员在《临床研究杂志》" JCI "上发表了一篇题为" Antioxidants stimulate BACH1-dependent tumor angiogenesis "的研究论文。 该研究显示,补充维生素C和E等抗氧化剂,可能会增加肺癌肿瘤内血管的形成,或加速肿瘤生长和转移。