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HBM7008是和铂医药利用HBICE平台开发的全球首创的靶向B7H4/4-1BB的双抗,利用靶向B7H4高表达的肿瘤细胞,在肿瘤微环境中特异性激活4-1BB, 避免出现类似Urelumab单抗的毒副作用。HBM7008目前处于临床前开发阶段,相关的临床前数据已经在2020年PEGS Boston会议期间发布。 此次安进与Teneobio的并购交易很可能会进一步坚定业...
HBM7008是和铂医药基于免疫细胞衔接器平台HBICETM而打造的针对B7H4×4-1BB靶点的T细胞衔接器全人源双抗。根据临床前数据和作用机理，HBM7008不仅很好地体现了公司双抗平台的优势，也完美诠释了和铂的创新布局和思路。首先，通过免疫细胞衔接器双抗激活免疫细胞。HBICETM是基于公司HCAb（新一代重链抗体发现平台）开发...
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M3205HB AK22-1M4201J BW100EAG-3P75 BW100EAG-3P60 BW50SAG-3P15 BW50SAG-3P30 BW63R BW50ZSAG BW50ZSAG AR22PCR-3174BAH165-2YP3 AH165-2YP2AH165-2YP3-11E3 AH165-2YP2-11E3 AH164-SP2B11 AH164-SP3B22AR22JCR-3C174AAR30G4L-10E3R DR30DOL-E4G DR30DOL-E4R AR30G4L-10H4W AR...
At room temperature, fluorobenzene and 1,3-difluorobenzene generate Rh(C6H4-2-F){xant(PiPr2)2} (5) and Rh(C6H3-2,6-F2){xant(PiPr2)2} (6), respectively. Complex 1 also promotes the B–H bond activation of pinacolborane (HBpin) and catecholborane (HBcat). The reactions initially...
c-di-GMP is a cellular second messenger that regulates diverse bacterial processes, including swimming, biofilm formation and virulence. However, in Stenotrophomonas maltophilia, a nosocomial pathogen that frequently infects immunodeficient or immunoinco
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HBM7008是和铂医药基于免疫细胞衔接器平台HBICETM而打造的针对B7H4×4-1BB靶点的T细胞衔接器全人源双抗。根据临床前数据和作用机理,HBM7008不仅很好地体现了公司双抗平台的优势,也完美诠释了和铂的创新布局和思路。 首先,通过免疫细胞衔接器双抗激活免疫细胞。HBICETM是基于公司HCAb(新一代重链抗体发现平台)开发的...