B-cell lymphoma is a type of blood cancer that affects the B lymphocytes of the immune system. They usually arise in the lymph nodes or in other lymphoid tissue, such as the spleen, bone marrow, blood or other organs. B-cell lymphomas are composed of large B lymphoid cells whose nuclear...
7. Reddy A, Zhang J, Davis NS, et al. Genetic and functional drivers of diffuse large B cell lymphoma. Cell. 2017;171(2):481-494.e15. 8. Li SY,Seegmiller AC, Lin P, et al. B-cell lymphomas with concurrent MYC ...
all kindsofB-cell lymphomas,while Imatinib is a chemical drug which is very effective [...] hksh.com hksh.com Mabthera/Rituximab乃常用於治療所有B細胞淋巴瘤的單克隆抗體,而Imatinib則是一種能有效治療慢性骨髓性白血病的化療藥物。 hksh.com
因此，免疫系统相关恶性肿瘤大部分都是由B细胞所引起的，最为常见的是弥散性大B细胞淋巴瘤（diffuse large B cell lymphomas，简称DLBCL），这类肿瘤根据其转录谱，一般可以分为生发中心B细胞样（germinal center B-like）DLBCL和活化的B细胞样（activated B-like）DLBCL两类【8】。近期，根据其不同的生物特征以及...
B-cell lymphomas are clonal tumors of mature and immature B cells that constitute the majority (80-85%) of non-Hodgkin lymphomas (NHLs). NHLs are a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. [1] NHL usually originates ...
et al. B-cell differentiation, apoptosis and proliferation in diffuse large B-cell lymphomas. Anticancer Res 25, 347–362 (2005). 33. Scott, D. W. et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene exspression in formalin-fixed paraffin-embedded tissue....
因此,免疫系统相关恶性肿瘤大部分都是由B细胞所引起的,最为常见的是弥散性大B细胞淋巴瘤(diffuse large B cell lymphomas,简称DLBCL),这类肿瘤根据其转录谱,一般可以分为生发中心B细胞样(germinal center B-like)DLBCL和活化的B细胞样(activated B-like)DLBCL两类【8】。...
[4] Willenbrock K,Brauninger A,Hansmann ML.Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases[J]. Br J Haematol,2007,138(6):733-739.
弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)是一组大细胞、侵袭性的恶性淋巴瘤,是成人淋巴瘤中最常见的类型,约占所有淋巴瘤的40%。DLBCL在临床表现、组织形态和预后等多方面具有高度异质性。DLBCL最初被分为三个亚型:ABC(activated B cell-like)、GCB(germinal center B cell-like)和Unclassified【...
[1].Swerdlow, S.H.,Campo,E., Pileri SA. ,et al., The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 2016. 127(20): p. 2375-90. [2].NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) . B-cell Lymphomas.Version 7.2017....