7. Reddy A, Zhang J, Davis NS, et al. Genetic and functional drivers of diffuse large B cell lymphoma. Cell. 2017;171(2):481-494.e15. 8. Li SY,Seegmiller AC, Lin P, et al. B-cell lymphomas with concurrent MYC ...
[1].Swerdlow, S.H.,Campo,E., Pileri SA. ,et al., The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 2016. 127(20): p. 2375-90. [2].NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) . B...
Lymphoma, T-CellThe B-cell lymphomas (BCLs) represent 80% to 90% of non-Hodgkin lymphomas in the Western world and include multiple lymphoma subtypes with different biologies, natural histories, morphologic characteristics, immunophenotypes, genetic features, prognoses, and responses to therapy. 1 ...
B-cell lymphoma is a type of blood cancer that affects the B lymphocytes of the immune system. They usually arise in the lymph nodes or in other lymphoid tissue, such as the spleen, bone marrow, blood or other organs. B-cell lymphomas are composed of large B lymphoid cells whose nuclear...
因此，免疫系统相关恶性肿瘤大部分都是由B细胞所引起的，最为常见的是弥散性大B细胞淋巴瘤（diffuse large B cell lymphomas，简称DLBCL），这类肿瘤根据其转录谱，一般可以分为生发中心B细胞样（germinal center B-like）DLBCL和活化的B细胞样（activated B-like）DLBCL两类【8】。近期，根据其不同的生物特征以及...
B-cell lymphomas are clonal tumors of mature and immature B cells that constitute the majority (80-85%) of non-Hodgkin lymphomas (NHLs). NHLs are a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. [1] NHL usually originates ...
B-cell lymphomas are tumours of immunocompetent cells, whose function it is to produce Ig. Correspondingly, Ig can be demonstrated in most B-cell lymphomas, either on the surface of tumour cells (slg) or in the cytoplasm (clg). In principle, the demonstration of clg is equivalent to Ig ...
[2] Lenz, G., Wright, G., Dave, S.S., et al. (2008b). Stromal gene signatures in large-Bcell lymphomas. N. Engl. J. Med. 359, 2313–2323.[3] Schmitz, R., Wright, G.W., Huang, D.W., et al. (2018). Genetics and pathogenesis of diffuse large B-cell lymphoma. N. ...
B-Cell Lymphoma FAQs What are the first symptoms of B-cell lymphoma?Swollen lymph nodes, fever, and unexplained weight loss are some of the symptoms you might notice. But it might take years before you notice any symptoms from certain B-cell lymphomas. Later on, symptoms may change or beco...
因此,免疫系统相关恶性肿瘤大部分都是由B细胞所引起的,最为常见的是弥散性大B细胞淋巴瘤(diffuse large B cell lymphomas,DLBCL)。根据转录谱的不同,DLBCL可以分为生发中心B细胞样(germinal center B-like)DLBCL和活化B细胞样(activated B-like)DLBCL两类。在这些类型中,临床上最为难治的是MCD/5型,这是活化B...