3. Zaliova M, Kotrova M, Bresolin S, et al. ETV6/RUNX1-like acute lymphoblastic leukemia: a novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype. Genes Chromosomes Cancer. 2017;56(8):608-61...
CD4−) as well as expression of stem cell and/or myeloid markers (HLA-DR,CD13, CD33, CD34). ETP-ALL has a gene expression profile similar to stem cell/myeloid progenitor cells [1]. Historically, ETP-ALL has been regarded as a subtype of T-ALL with worse prognosis and higher relapse...
Mullighan CG, Su X, Zhang J, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360:470-480; Stanulla M, Dagdan E,Zaliova M, et al. IKZF1plus defines a new minimal residual disease-dependent very-poor prognostic profile in pediatric B-cell ...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes. ...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic st...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes....
Precursor B cell acute lymphoblastic leukemia (BCP-ALL) is a common hematological malignancy in children. Although effective treatment has been available, the prognosis is poor and long-term survival rate is still extremely low in children with relapsed or refractory BCP-ALL. BCP-ALL has been clas...
B-cell acute lymphoblastic leukemia (B-ALLmonoclonal antibodiesrelapsed and refractory diseaserituximabSummary This chapter addresses the management of adult B-cell acute lymphoblastic leukemia (ALL). The front-line strategy is similar to that in pediatrics: induction chemotherapy, multiple rounds of ...
Philadelphia chromosome-positive acute lymphoblastic leukemia (PH + ALL) is the most common cytogenetic abnormality of B-ALL in adults and is associated with poor prognosis. Previously, the only curative treatment option in PH + ALL was allogeneic hematopoietic stem cell transplantation (Allo...
B-cell lymphomasand range from well differentiated to large cell and anaplastic. Growth tends to progress along lymphatic pathways (Fig. 11.6). Unlike LIP, the tumor cells often invade the airways, vessels, and pleura, indicating their malignant potential. Prognosis is dependent on the cell type...