B cell lineage acute lymphoblastic leukemia is the most common leukemia occurring in children and young adults and is the leading cause of cancer related deaths. The 5year overall survival outcome in children with B-ALL has improved significantly in the last few decades. In the past, the ...
B-cell chroniclymphocytic leukemia(CLL) is one of the most commonly occurring leukemias in the Western Hemisphere, accounting for approximately one third of all leukemias. CLL was initially described by Dameshek as an accumulative disorder of abnormal immunologically incompetent lymphocytes.1Our understandi...
Twenty patients with poor prognosis B-cell chronic lymphocytic leukemia (B-CLL) underwent uniform high-dose chemoradiotherapy followed by rescue with multi... SN Rabinowe,RJ Soiffer,JG Gribben,... - 《Blood》 被引量: 537发表: 1993年 ATM mutations in B-cell chronic lymphocytic leukemia. Mutati...
Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we ...
EP: 1.Relapsed Refractory B-Cell ALL: Patient Prognosis EP: 2.Relapsed Refractory B-Cell ALL: Treatment Overview EP: 3.CAR T Therapy for Relapsed/Refractory B-Cell ALL: Selecting Appropriate Patients EP: 4.CAR-T Therapy for Relapsed/Refractory B-Cell ALL: Sequencing Decisions EP: 5.Relapse...
Markers of high-risk status at the time of diagnosis include age ≥10 years and/or initialwhite blood cell count≥50,000/μL. The prognosis for B-ALL has been better characterized because of recent insights into the molecular genomic pathways of this disease. Long-term disease-free survival ...
www.nature.com/scientificreports OPEN received: 02 April 2015 accepted: 05 January 2016 Published: 09 February 2016 The distinct clinical features and prognosis of the CD10+MUM1+ and CD10−Bcl6−MUM1− diffuse large B-cell lymphoma Ting-Xun Lu1,2,*,Yi Miao1,*, Jia-Zhu Wu...
prognostic profile in pediatric B-cell precursor acute lymphoblastic leukemia.J Clin Oncol 2018;36:1240-1249. Mangum DS, Meyer JA, Mason CC, et al. Association of combined focal 22q11.22 deletion and IKZF1 alterations with outcomes inchildhood acute lymphoblastic leukemia. JAMA Oncol 2021;7:...
Silencing Pre-B-cell leukemia homeobox 3 decreases the proliferation of human glioma cells in vitro and in vivo. Among primary brain tumors, gliomas are the most common and most aggressive, with a poor prognosis and limited treatment options. Thus, it is essential to ... Xiupeng,Xu,Ning,....
Flow cytometry study was suggestive of pro‐B-cell acute lymphoblastic leukemia (B-ALL; CD19+TdT+CD10−) with aberrant partial expression of CD13 and CD33. 【翻译】流式细胞学检查提示为pro原始B淋巴细胞白血病(B-ALL,CD19+TdT+CD10−),...