The association between obesity and survival in non-Hodgkin lymphoma is unclear. Using the Ontario Cancer Registry we conducted a retrospective analysis of incident cases of aggressive-histology B-cell lymphoma treated with a rituximab-containing regimen with curative intent between 2008–2016. 6246 ...
Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we ...
3.4B-cell chronic lymphoid leukemia (B-CLL) Echis also closely associated with other rare cancers. B-cell chronic lymphoid leukemia (B-CLL) is a highly heterogeneous humanmalignancy. One of the common features of B-CLL cells is their prolonged survival in peripheral blood, which is due to a...
BAFF AND APRIL: a tutorial on B cell survival. Annu. Rev. Immunol. 21, 231–264 (2003). Article CAS PubMed Google Scholar Furie, R. et al. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with ...
, as further discussed below. It is thus clear that t(4;11)+ pro-B ALL has a lower mutation rate than other subtypes of B cell leukaemia, suggesting that MLL-AF4 alone is sufficient to initiate disease. Several attempts have been made to generate a mouse model for MLL-AF4+ leukaemia...
在Lancet Oncology、Cell、Blood、Leukemia、JHO等SCI收录杂志上发表学术论文280余篇,以第一获奖人获得国家科技进步二等奖1项、浙江省科技进步一等奖2项 -王华锋 教授- 浙江大学医学院附属第一医院 血液科 副教授/副主任医师/硕...
Normal immature B cells had low levels of bcl-2 protein; the intensity of fluorescence, expressed as molecules of soluble fluorochrome per cell, within CD10+ cells was 3,460 ± 1,050 (mean ± SD; 5 samples). In 16 cases of B-lineage acute lymphoblastic leukemia (ALL), cells had ...
Astier AL, Xu R, Svoboda M, Hinds E, Munoz O, de Beaumont R et al. Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival.Blood2003;101: 1118–1127. ...
www.nature.com/scientificreports OPEN received: 04 February 2016 accepted: 25 May 2016 Published: 13 June 2016 A potential panel of six-long non- coding RNA signature to improve survival prediction of diffuse large- B-cell lymphoma Jie Sun*, Liang Cheng*, Hongbo Shi*, Zhaoyue ...
Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Article Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer among children and remains a frequent cause of death from cancer before 20 years of age [1,2]. S...