The autophagy-lysosomal pathway (ALP) is involved in the degradation of long-lived proteins. Deficits in the ALP result in protein aggregation, generation of toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheimer's, Parkinson's, Huntington's, and prion...
The failure to treat brain tumors is due to the ineffectiveness of conventional methods in causing cell death. This has resulted in the exploration of autophagy as another way to induce glioma cell demise. Common brain tumor alterations such as p53, PTEN, AKT, NF1, and EGFR regulate autophagy...
Interestingly, many of these genetic factors, such as LRRK2, GBA, SMPD1, SNCA, PARK2, PINK1, PARK7, SCARB2, and others, are involved in the autophagy-lysosome pathway (ALP). Some of these genes encode lysosomal enzymes, whereas others correspond to proteins that are involved in transport...
Autophagy-lysosomal pathway as potential therapeutic target in Parkinson's disease. Cells. 2021;10(12):1–40. doi:10.3390/cells10123547 49. Saha T. LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy. Autophagy. 2012;8(11):1643– 1656. doi:...
The autophagy-lysosomal pathway (ALP) is a cellular process that enables cells to degrade intracellular long-lived proteins and organelles via lysosome. ALP deregulation has been linked to various human diseases [16,17,18,19]. In the pathophysiology of AD, the importance of ALP in Aβ and p...
2020年12月27日,德国汉堡-埃彭多夫大学医学中心实验药理学和毒理学研究所Lucie Carrier课题组在《Autophagy》(2019 IF:9.770)发表题为“Ahigh-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway”的研究论文。该研究为ZNF418激活ALP、抑制UP...
The autophagy鈥搇ysosomal pathway (ALP) and the ubiquitin鈥損roteasome system (UPS) are the two major intracellular proteolytic systems that mediate protein turnover in eukaryotes. Although a crosstalk exists between these two systems, it is still unclear how UPS and ALP interact in vivo. Here,...
Collectively, our research confirms that harmol activates the AMPK-mTOR-TFEB mediated ALP pathway in vitro and in vivo, contributing to the degradation of pathogenic proteins, the restoration of autophagic flux, and lysosomal biogenesis, and the improvement of motor impairment. These results increase ...
NDs are characterized by the aggregation of a vast population of proteins that would normally undergo degradation via the two main catabolism pathways, the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP). Ubiquitin signaling is a cascade reaction of tagging a ubiquitin res...
Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosomal pathway (ALP). Here, we cloned a novel splicing variant of TFEB, comprising 281 amino acids (hereafter referred to as small TFEB), and lacking the helix-loop-helix (HLH) and leucine zipper (LZ) motifs present ...