Lysosomal calcium is emerging as a modulator of autophagy and lysosomal compartment, an obligatory partner to complete the autophagic pathway. A variety of specific signals such as nutrient deprivation or oxidative stress can trigger lysosomal calcium-mediated nuclear translocation of the transcription ...
Autophagy defects in a mouse model lacking Atg7 in β-cells (Atg7f/f:RIP-Cre mice) resulted in progressive β-cell loss and impaired glucose tolerance28,29. This phenotype suggests that autophagy is fundamental for β-cell survival. In addition, autophagy is indispensable for various physiological...
Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB (2015). Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat. Cell Biol. 17, 288-299.M. McBrayer, R.A. Nixon, Lysosome ... D Medina,SD Paola,I Peluso,... - 《Nature Cell Biology》 被引量...
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat. Rev. Mol. Cell Biol. 14, 283–296 (2013). CAS PubMed PubMed Central Google Scholar Medina, D. L. & Ballabio, A. Lysosomal calcium regulates autophagy. Autophagy 11, 970–971 (2015). PubMed...
animal model, wherein we have shown that the Lafora bodies might contribute to the impairment in the endosomalâlysosomal and autophagy pathways.do... R Puri,S Ganesh - 《Autophagy》 被引量: 29发表: 2012年 Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress ...
In recent years biochemical and cell biology studies of LSDs have revealed an ample spectrum of abnormalities in a variety of cellular functions. These include defects in signaling pathways, calcium homeostasis, lipid biosynthesis and degradation and intracellular trafficking. Lysosomes also play a ...
Filoviruses require TPC function for release of the viral genome into the host cell [18], and a pharmacological block of TPCs by trans-Ned-19 (NED19) or other calcium channel blockers inhibits viral infectivity [18]. The exact role of TPCs in viral infection is not clear. Knockdown of ...
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat. Commun. 3, 731 (2012). Article PubMed CAS Google Scholar Zhang, X. et al. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat. Commun. 7, 12109 (2016). ...
They play an essential role in calcium regulation and have emerged as key signaling hubs in controlling the nutrient response. Maintaining lysosomal integrity and function is therefore crucial for cellular homeostasis. Different forms of stress can induce lysosomal membrane permeabilization (LMP), ...
Transcription factor EB (TFEB), a well-known master regulator of autophagy and lysosomal biogenesis, is a member of the microphthalmia family of transcription factors (MiT family). Over the years, TFEB has been shown to have diverse roles in various phys