The autophagy-lysosomal pathway in neurodegeneration: a TFEB perspective. Trends Neurosci 2016; 39: 221-234.Martini-Stoica, H., Xu, Y., Ballabio, A. and Zheng, H. (2016) The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends Neurosci., 39, 221-234....
In Alzheimer's disease, the already declining autophagy-lysosomal function is exacerbated by an increased need for clearance of damaged proteins and organelles in aged cells. Recent evidence suggests that numerous diseases are linked to impaired autophagy upstream of lysosomes. In this way, a ...
Conclusions Internalized EGF-E4orf4 can be slowly degraded via endosome-lysosome pathway. 结论融合蛋白EGF-E4orf4在细胞内经内体-溶酶体途径发生缓慢降解;在MDA-MB-231和BGC823细胞中,融合蛋白的作用特点存在明显差异,可能是导致融合蛋白对二者抑瘤率不同的原因之一。4) Lysosome apoptotic pathway 溶酶体凋亡...
We investigated roles for inflammatory responses in MCD pathogenesis by examining the lysosomal-autophagy pathway and activation of pyroptosis in MCD keratocytes. Normal and lesioned keratocytes were obtained from MCD patients undergoing corneal transplantation. The keratocytes were subjected to gene ...
The autophagy–lysosomal pathway is a self‐catabolic process by which dysfunctional or unnecessary intracellular components are degraded by lysosomal enzymes. Proper function of this pathway is critical for maintaining cell homeostasis and survival. Subarachnoid haemorrhage (SAH) is one of the most devast...
Nowosad, A., Jeannot, P., Callot, C.et al.p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth.Nat Cell Biol22, 1076–1090 (2020). https://doi.org/10.1038/s41556-020-0554-4 ...
We herein demonstrated that the secretion of TDP-43 was stimulated by the inhibition of the autophagy-lysosomal pathway driven by progranulin (PGRN), a causal protein of frontotemporal lobar degeneration. Among modulators of autophagy, only vacuolar-ATPase inhibitors, such as bafilomycin A1 (Baf), ...
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell... CDKN1B/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cellsCDKN1B/p27/Kip1mTOR... A Nowosa...
6. Autophagy is also required for pluripotency of cancer stem cells and has also been reported to be necessary for the maintenance of stemness in muscle stem cells7,8. For coordinating the autophagy–lysosomal pathway, a finely tuned transcriptional regulation of this pathway enables cells to ...
The laforin-deficient brain also reveals the proliferation of enlarged lysosomes, lipofuscin granules, amyloid-β peptides and increased levels of insoluble form of ubiquitinated protein, indicating a significant impairment in the cellular degradative pathway. Further, abnormal dendrites and increased glios...