Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy 2007 ; 3:154 - 7; http://dx.doi.org/ 10.4161/auto.3634 ; PMID: 17204842 [Taylor & Francis Online] ,Kawai A, Uchiyama H, Takano S, Nakamura N, Ohkuma S. Autophagosome-lysosome fusion depends...
(4,5)P2, an inhibitor of the calcium channel mucolipin-1 that controls autophagosome–lysosome fusion. Hence, autophagosomes accumulate in OCRL-depleted cells and in the kidneys of Lowe syndrome patients. Importantly, boosting the activity of mucolipin-1 with selective agonists restores the ...
V-ATPase is not required for autophagosome–lysosome fusion BafA1, a chemical inhibitor of the V-ATPase, is commonly used to block autophagosome–lysosome fusion in mammalian cell culture studies, and causes an accumulation of autophagosomes upon autophagy induction14,24. This phenomenon is reversible...
Chen J. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy. 2020 May;16(5):797-810. doi: 10.1080/15548627.2019.1637199. Epub 2019 Jul 4. PMID: 31251111; PMCID: PMC7144865.
BASIC RESEARCH PAPER Autophagy 11:9, 1608--1622; September 2015; © 2015 Taylor & Francis Group, LLC Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33AD251E mutation Yuanli Zhen1,2 and Wei Li1,3,4,* 1State Key Laboratory of Molecular Developmental Biology...
In this punctum, we discuss how the C9orf72-RAB39A-HOPS axis function regulates autophagosome-lysosome fusion. 展开 关键词: Autophagosome-lysosome fusion C9orf72 HOPS complex membrane tethering RAB39A DOI: 10.1080/15548627.2023.2291938 年份: 2024 ...
Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells et al. Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells. J. Lipid Res. 56, ... Janikiewicz,...
Autophagosome-lysosome fusion mediated by SNARE complexes is an essential step in autophagy.Two SNAP29-containing SNARE complexes have been extensively studied in starvation-induced bulk autophagy,while the relevant SNARE complexes in other types of autophagy occurring under non-starvation conditions have ...
Moreover, vacuole formation was inhibited by the knockdown of progranulin (PGRN), a regulator of autophagosome-lysosome fusion, and promoted by its overexpression. The present results suggest the potential of Abe-/Vac-induced vacuole-like autolysosomes as a tool for evaluating autophagosome-lysosome ...
SETD2 promotes the expression of a long ATG14 isoform, ATG14L, that contains an N-terminal cysteine repeats domain, essential for the efficient fusion of the autophagosome with the lysosome, that is absent in the short ATG14 isoform, ATG14S. Accordingly, SETD2 loss of function decreases ...