A wide range of nanoparticles, such as polymeric nanogels, liposomes, metallic nanoparticles, protein, or DNA nano-assemblies, have been employed in the fabrication of nanocarriers. In this review, we describe several ATP-responsive drug delivery systems based on the various carriers and discuss the...
We demonstrate that polymeric nanocarriers functionalized with an ATP-binding aptamer-incorporated DNA motif can selectively release the intercalating doxorubicin via a conformational switch when in an ATP-rich environment. The half-maximal inhibitory concentration of ATP-responsive nanovehicles is 0.24μM ...
Molecularly imprinted polymers with DNA aptamer fragments as macromonomers. ACS Appl. Mater. Interfaces 8, 6371–6378 (2016). CAS PubMed Google Scholar Aumiller, W. M. Jr. & Keating, C. D. Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles...
Thus, the strategy based on structure-switching aptamer triggering metal-enhanced fluorescence (SATMEF) for Cy7 is designed to detect ATP via “enhanced fluorescence” signals, and the maximum fluorescence enhancement by the approach of SATMEF reaches 5.63-fold. We applied this DNA nanoswitch for ...
谭拥军教授 StudiesonATPResponsiveControlledReleaseSystemBasedon AptamerCappedMesoporousSilicaNanoparticles by ZHAOYingxiang B.S.(XiangtanUniversity)2010 Athesissubmittedinpartialsatisfactionofthe Requirementsforthedegreeof MasterofScience in Biochemistryandmolecularbiology inthe GraduateSchool of HunanUniversity Supervisor...
In the presence of a single-strand DNA (DNA-L), fluorescence was quenched because DNA-L was adsorbed on the surface of GO, resulting in FRET. When ATP was added, the ATP aptamer (the red fragment in DNA-L) formed a hairpin with ATP, and another fragment (the blue fragment in DNA-...
Recently, MOFs have emerged as carrier materials for constructing biological platforms. 27–29 Most representatively, Willner et al. assembled a series ofstimuli-responsive DNA-functionalized MOFsas drug carriers in cancer cells.30 装配了一系列刺激反应的DNA功能化MOF作为癌细胞中的药物载体。30 O. Farha...
Aptamer-based self-assembled supramolecular vesicles for pH-responsive targeted drug delivery Article 07 December 2016 Achieving Selective Targeting Using Engineered Nanomaterials Chapter © 2019 Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalyst...
ATP-responsive systemsaptamerCancernanoparticlesDiagnosisIn recent years, many stimuli-triggered drug delivery platforms have been designed to deliver drugs accurately to specific sites and reduce their side effectsdoi:10.2139/ssrn.3687916Sameiyan, Elham...
Drug Delivery: ATP-Responsive Aptamer-Based Metal-Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs (Adv. Funct. Mater. 37/2017).doi:10.1002/adfm.201770220DRUG delivery devicesMETAL organic chemical vapor depositionChen...