adenosine triphosphate (ATP)-responsiveP-glycoprotein (P-gp) suppressionnanocapsulesmulti-model tumor therapyMultidrug resistance (MDR) restricts chemotherapy efficacy due to P-glycoprotein (P-gp) mediated drug efflux, whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges...
These results indicate that the Triton X-100-modifiedATP-responsive transfection agent is a promising gene delivery vectorfor target gene silencing in vitro and in vivo. 展开 关键词: lysosome escape cell penetration antitumor gene silencing Triton ...
Reversible Covalent Cross-Linked Polycations with Enhanced Stability and ATP-Responsive Behavior for Improved siRNA DeliveryCationic polyplex as commonly used ... Zhou,Zhanwei,Zhang,... - 《Biomacromolecules》 被引量: 0发表: 2018年 Impact of tumor-specific targeting on the biodistribution and efficacy...
the doxorubicin-loaded chimeras effectively inhibited the growth of cancer cell lines and reduced the cytotoxic effect on the normal cells. Overall, the results of this study show that the AS1411–ATP aptamer chimera could be used as an innovative approach for the selective delivery of doxorubicin...
ATP/pH dual responsive nanoparticle with d-[des-Arg10]kallidin mediated efficient in vivo targeting drug delivery. Small. 2017;13(3):1602494.Zhang Y, Lu Y, Wang F, An S, Zhang Y, Sun T,et al. ATP/pH dual responsive nanoparticle with d-[des-Arg10]kallidin mediated efficient in vivo...
Further characterization of ATP-responsive cells revealed that the highest concentration of terminal deoxynucleotidyl transferase, a marker enzyme for precursor T cells, was present in these cells. ATP-mediated stimulation of DNA synthesis may, therefore, serve as a specific marker restricted to a ...
M.-L. WuW.T. MasonG.J. LawThe Journal of PhysiologyWu M-L. Mason WT. Law GJ. (1993) ATP increases intracellular Ca*+ in TRH-responsive rat anterior pituitary cells. J. Physiol.. 473, P4.5.
A dual-stimuli responsive i-motif/nanoflare for molecule detection in lysosomes was designed. By combining the structure-switchable i-motif sequence and high recognition ability of an adenosine triphosphate (ATP) aptamer, subcellular sensing and visualization sensing of ATP in lysosomes at the subcellul...
A novel label-free fluorescent sensing scheme for sensitive and selective detection of NAD+and ATP has been developed based on dumbbell probe-mediated rolling circle amplification (D-RCA)-responsive G-quadruplex formation. This approach can detect 0.5 pM for ATP and 100 fM for NAD+, much lower...
In the present study we identified the mHags recognized by this CTL clone to be encoded by the ATP-dependent interferon-responsive (ADIR) gene.37 This gene was found to be highly expressed in the MM cells, in other hematopoietic tumors, as well as nonhematopoietic tumor cell lines. Recogniti...