[1]Cai X, Yao Y, Teng F, Li Y, Wu L, Yan W, Lin N. The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. Int Immunopharmacol.2021 Dec;101(Pt A):108297. doi: 10.1016/j.intimp.2021.108297. Epub 2021 Oct 29. PMID: 34717202.[2]Figliuolo V...
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人体损伤细胞可释放大量ATP到细胞外,作用于T细胞膜上的P2X7受体,促进T细胞产生并分泌免疫活性物质诱发炎症,继而引起发热。下列叙述正确的是( )A. 炎症反应发生时
Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. Elife. 2018 Aug 3;7:e36217. doi: 10.7554/eLife.36217. PMI...
P2X7 purinergic receptors participate in the expression and extinction processes of contextual fear conditioning memory in mice[J]. Neuropharmacology, 2018, 128: 474-481.[10] Kittner H, Franke H, Harsch J I, et al. Enha...
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Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction[J]. Archives of Pharmacal Research, 2023, 46(8):694-712. [3] CaoM J, Huang X W, Zou J L, et al. Attenuation of Microglial Activation and Pyroptosis by Inhibition of P2X7 ...
[3] Neves AR, Castelo-Branco MT, Figliuolo VR, Bernardazzi C, Buongusto F, Yoshimoto A, Nanini HF, Coutinho CM, Carneiro AJ, Coutinho-Silva R, de Souza HS. Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease. Inflam...
炎症反应是机体对于外界刺激的一种防御反应。炎症状态下,损伤或濒死细胞可释放大量ATP到细胞外,作用于靶细胞膜上的P2X7受体,促进靶细胞产生并分泌淋巴因子等物质,促进炎症反应。慢性炎症可导致许多疾病,知过做、哮喘或风湿性关节炎。一种纳米抗体可以阻断炎症并减轻疼痛,其作用机理如图。下列分析正确的是( ) A. ATP...
炎症反应是机体对于外界刺激的一种防御反应。炎症状态下,损伤或濒死细胞可释放大量ATP到细胞外,作用于靶细胞膜上的P2X7受体,促进靶细胞产生并分泌淋巴因子等物质,促进炎症反应。长期或慢性炎症可导致许多疾病,如过敏、哮喘或类风湿性关节炎。一种纳米抗体可以阻断炎症并减轻疼痛,其作用机理如图。(1)坏死细胞的细胞膜通...