ATP1A2 mutations are loss-of-function mutations that are thought to result in slower glial reuptake of glutamate and thus hyperexcitability. From: Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (Fifth Edition), 2015 ...
Sign in to download full-size image Figure 2.Diagram of the ATP synthase. Note that during ATP synthesis, subunitsc,γ, andɛrotate as a complete unit with respect to the other (fixed) subunits. Mechanism of ATP Synthesis ATP synthesis is driven by the rotation of the singleγ-subunit,...
adenosine - (biochemistry) a nucleoside that is a structural component of nucleic acids; it is present in all living cells in a combined form as a constituent of DNA and RNA and ADP and ATP and AMP biochemistry - the organic chemistry of compounds and processes occurring in organisms; the ...
Full activity is defined as the identical assay but with no drug added. Source Data Extended Data Fig. 2 Cryo-EM data processing of M. tuberculosis ATP synthase in the apo form and human ATP synthase in complex with BDQ. a, M. tuberculosis ATP synthase in the apo form. b, Human ATP ...
form full junctions by ligation, rendering alternating DySS DNA polymers. Those are exclusively brought into close proximity upon DySS polymerization (Fig.3f), because all three tiles are separated from each other in the absence of fuel due to very weak base pairing at 37 °C (Supplementary...
Full size table WherevD= specific activity in the presence of C8D-ATP vH= specific activity in the presence of ATP. The calculation of KIEDwas used as the extent of the KIEDis instructive in the putative role that the C8H of ATP plays in the regulation of phosphoryl transfer as in the ...
When 1 mM PGO was reacted with SR-ATPase at 30掳C at pH 8.5, PGO was bound to the ATPase molecule in two-to-one stoichiometry with concomitant loss of activity of the ATPase to form the phosphorylated intermediate (E-P). ATP and ADP prevented the binding of PGO and thereby protected ...
Full size table High peak torque, low peak torque, and torque fatigue of the leg muscles measured over the three exercise sets are shown in Figure 2. No significant difference was found for high peak torque (Figure 2A). Overall treatment main effect of supplementing 400 mg of ATP approached...
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Although Z-VAD markedly attenuated the MG132-induced decrease in full-length (i.e. with the retained autoinhibitory segment) Panx1 levels, the overall expression of intact Panx1 protein remained lower than in control Jurkat cells or cells treated with only Z-VAD. Likewise, the additional ...