of F1-ATPase from bovine heart mitochondria. Nature 370, 621–628 11. Itoh, H. et al. Mechanically 465–468 (2004). driven ATP synthesis by F1-ATPase. Nature 427, 12. Rondelez, Y. et al. molecules. Nature Highly coupled ATP synthesis 433, 773–777 (2005). by F1-ATPase single 13...
MitochondriaSH-SY5YGlibenclamideDiazoxideRotenoneInward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several decades. Modulators of KATP channels are well-established treatments for metabolic as well as cardiovascular diseases. Experimental studies have...
of F1-ATPase from bovine heart mitochondria. Nature 370, 621–628 11. Itoh, H. et al. Mechanically 465–468 (2004). driven ATP synthesis by F1-ATPase. Nature 427, 12. Rondelez, Y. et al. molecules. Nature Highly coupled ATP synthesis 433, 773–777 (2005). by F1-ATPase single 13...
aSub-state 3A Fofocused cryo-EM map of theE. coliFostator, masked to remove c-ring for clarity (subunit a in orange, subunit b in pink and lipid-like densities in wheat). Highlighted orange region in the intact enzyme on right shows area depicted, with viewpoint indicated with an eye....
FO membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase Biochemistry, 33 (25) (1994), pp. 7971-7978, 10.1021/bi00191a026 View in ScopusGoogle Scholar Couoh-Cardel et al., 2010 S.J. Couoh-Cardel, S. Uribe-Carvaja...
Akt also promotes hexokinase association with mitochondria and activates phosphofructokinase (Deprez et al., 1997; Gottlob et al., 2001), which are rate-limiting steps of glycolysis. Furthermore, PIP3 recruits and activates the guanine nucleotide exchange factor for Rho GTPase, which induces actin ...
This machinery is indispensable for oxidative phosphorylation and photophosphorylation in a ROS producing cellular environment of aerobic organisms [1], [13], [14]. It was shown that ATP synthase disorders promote ROS generation in mitochondria [15]. In plants, kinetic alterations of the ATP ...
Interestingly, ganglioside GD3 acts as an apoptotic regulator by interacting with mitochondria and recruiting apoptotic pathways (89). GM1-accumulation at GSL-enriched microdomains in mitochondrial-associated ER membranes may influence Ca2+-mediated apoptotic signaling (90). Diabetic heart tissue has ...
F-type H+-ATPases catalyse ATP synthesis and ATP hydrolysis coupled with a transmembrane proton transport in bacteria, chloroplasts and mitochondria [1], [2]. These enzymes contain a membrane-inserted F0-part involved in proton translocation and a hydrophilic F1-part containing six nucleotide bindi...
MitochondriaCalcium signalingThe neurotoxicity of manganese [Mn] is due in part to glutamate excitotoxicity. Release of ATP by astrocytes is a critical modulator of glutamatergic neurotransmission, which is regulated by calcium (Ca 2+) waves that propagate through astrocytic networks in response to ...