MITOCHONDRIACARDIAC surgeryHEART metabolism disordersHUMAN experimentationOXIDATIVE phosphorylationCardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic R
1. Klingenberg,M. The ADP and ATP transport in mitochondria and its carrier.Biochimica et biophysica acta 1778, 1978-2021,doi:10.1016/j.bbamem.2008.04.011 (2008). 2. Ruprecht,J. J. et al. Structures of yeastmitochondrial ADP/AT...
Such a binding suppresses ATP synthase activity, leading to the activation of AMPK, improving glucose metabolism, and rescuing mitochondria from hyperglycaemia-induced fragmentation. The mode of action of Cr(III) in cells also holds true in type II diabetic male mice. Through this study, we ...
[8].Meier J J, Bonadonna R C. Role of Reduced β-Cell Mass Versus Impaired β-Cell Function in the Pathogenesis of Type 2 Diabetes[J]. Diabetes Care, 2013.DOI:10.2337/dcS13-2008 [9].Anello M, Lupi R, Spampina...
Mitochondria serve a crucial role in cell growth and proliferation by supporting both ATP synthesis and the production of macromolecular precursors. Whereas oxidative phosphorylation (OXPHOS) depends mainly on the oxidation of intermediates from the tricarboxylic acid cycle, the mitochondrial production of ...
(AGP protein). It has been shown recently that DAPIT has a role in maintaining ATP synthase amount in mitochondria and therefore possibly can influence cellular energy metabolism (Ohsakaya et al.2011). The functional role of the 6.8-kDa proteolipid as ATP synthase-associated protein still has ...
The phosphate/oxygen (P/O) ratio, which is defined as the amount of ATP generated per molecule of oxygen consumed by mitochondria, influences growth and reproductive output, and the P/O is regulated by the generation of reactive oxygen species [13]. The dependence on the intracellular ATP ...
ATP检测试剂盒(ATP Assay Kit)可以用于检测普通溶液、细胞或组织内的ATP(adenosine 5'-triphosphate)水平。细胞和组织样品一步裂解即可完成样品制备,检测灵敏度高达1nM,化学发光可以持续稳定达30分钟,并且获得的样品还可以同时进行Western检测。 ATP,作为最重要的能量分子,在细胞的各种生理、病理过程中起着重要作用。ATP...
assess mitochondria function and activity, or detect bacterial and microbial contamination. This luciferase-based ATP detection kit provides a versatile and sensitive method for measuring ATP production in various enzymatic reactions, including ATPase and NADPH oxidase, and monitoring ATP release from cells...
Moreover, we demonstrated that lifespan extension by Y82E9BR.3 RNAi is associated with reduced mitochondrial function, as well as the suppression of complex I activity in mitochondria. Unexpectedly, Y82E9BR.3 RNAi knock down did not influence the whole-worm ATP level. Our findings first reveal...