肌萎缩性侧索硬化(Amyotrophic lateral sclerosis, ALS)是一种成人发病的神经退行性疾病,以上、下运动神经元进行性变性丢失为主要特征。现有研究证据表明,ATAXIN-2(ATXN2)基因中等长度的CAG重复扩增显著增加ALS发病风险,并促进TDP43病理改变。有趣的...
21776-1-AP targets Ataxin 2 in WB, IHC, IF/ICC, IF-P, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Reactivity human, mouse, rat Cited Reactivity human, mouse, rat Host / Isotype Rabbit / IgG Class Polyclonal Type Antibody Immunogen Ataxin 2...
Protein Name: Ataxin-2 Human Gene Id: 6311 Swiss-Prot: Q99700 Formulation: Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide Source: Rabbit Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Concentrat...
Cell酵母Ataxin-2蛋白低复杂度结构域中的甲硫氨酸可通过感受氧化压力来调控相分 离 酵母细胞在营养受限的条件下，会发生自噬过程，其中Pbp1蛋白通过相分离的方式来抑制 TORC1蛋白的活性，以调节自噬过程中TOR通路的活性（同期Cell）。作者发现相比于其它相 分离的蛋白质，例如FUS等，它们主要通过低复杂结构域中较多的...
Ataxin-2 plays crucial roles at different stages of the regulation of posttranslational gene expression. ATXN2 is also directly implicated in the regulation of neural function by influencing specific molecular and cellular pathways. Genetic expansion of a poly‐glutamine tract in human ATXN2 has been...
68316-1-Ig targets Ataxin 2 in WB, IHC, IF-P, ELISA applications and shows reactivity with Human, Mouse, Rat samples. Tested Applications WB, IHC, IF-P, ELISA Application Description Tested Reactivity Human, Mouse, Rat Immunogen Ataxin 2 fusion protein Ag17402 种属同源性预测 Host / Isot...
5月27日,Journal of Biological Chemistry正式发表了中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)胡红雨研究组的研究论文:“PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6”。该研究揭示了多聚谷氨酰胺(Polyglutamine, PolyQ...
通过在果蝇中使用RNAi敲低Atx2,可以显著恢复TDP-43表达相关的睡眠缺陷(图4A-G),表明Atx2在调节TDP-43相关睡眠异常中具有关键作用。 图4. Atx2敲低可以挽救TDP-43诱导的睡眠紊乱。 4.小分子代谢途径介导敲低Atx2对TDP-43睡眠紊乱的挽救。 结合RNA测序...
上海玉博生物科技有限公司 主要致力于“ATAXIN-2 MAB 50UG 22 BD Pharmingen-611378”的生产销售。多年的“ATAXIN-2 MAB 50UG 22 BD Pharmingen-611378”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前
点击查看官网产品详细介绍:Ataxin 2 antibody|Ataxin 2兔多克隆抗体宿主来源于:Rabbit,克隆性:polyclonal,适用种属:Human, Mouse, Rat,验证应用:ELISA, IHC, IF, WB, IP--- 如果您需要订购请您在线咨询我们QQ:3338912448或者与您所在区域的经销商/代理商联系 ---...