肌萎缩性侧索硬化(Amyotrophic lateral sclerosis, ALS)是一种成人发病的神经退行性疾病,以上、下运动神经元进行性变性丢失为主要特征。现有研究证据表明,ATAXIN-2(ATXN2)基因中等长度的CAG重复扩增显著增加ALS发病风险,并促进TDP43病理改变。有趣的是...
通过在果蝇中使用RNAi敲低Atx2,可以显著恢复TDP-43表达相关的睡眠缺陷(图4A-G),表明Atx2在调节TDP-43相关睡眠异常中具有关键作用。 图4. Atx2敲低可以挽救TDP-43诱导的睡眠紊乱。 4.小分子代谢途径介导敲低Atx2对TDP-43睡眠紊乱的挽救。 结合RNA测序...
Intermediate-length repeat expansions inATAXIN-2(ATXN2) are one of the strongest genetic risk factors for ALS, reported to have a frequency of 4,7% in ALS patients12. ATXN2 repeat expansions were initially linked to spinocerebellar ataxia type 2 (SCA2)17,18and were subsequently associated with...
support the central role of ATXN2 protein neurotoxicity in SCA2 pathogenesis. This neurotoxicity involves multiple cellular pathways, including messenger RNA (mRNA) maturation, translation, and endocytosis [77]. In all CUG/CAG diseases, repeat sequences containing mutant transcripts form RNA foci, cont...
免疫原 Ataxin 2 fusion protein Ag17402 种属同源性预测 宿主/亚型 Mouse / IgM 抗体类别 Monoclonal 产品类型 Antibody 全称 ataxin 2 别名 ataxin 2, ATX2, ATXN2, FLJ46772, SCA2, TNRC13 计算分子量 1313 aa, 140 kDa 观测分子量 140-150 kDa GenBank蛋白编号 BC114546 基因名称 ATXN2 Gene ID (...
5月27日,Journal of Biological Chemistry正式发表了中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)胡红雨研究组的研究论文:“PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6”。该研究揭示了多聚谷氨酰胺(Polyglutamine, PolyQ...
5月27日,Journal of Biological Chemistry正式发表了中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)胡红雨研究组的研究论文:“PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6”。该研究揭示了多聚谷氨酰胺(Polyglutamine, PolyQ...
Ataxin 2/ATXN2抗体 产品官方链接 价格:面议 品牌:百奥莱博 产地:北京 最新更新日期:2024-06-20 14:12 我要询单 QQ交流 北京百奥莱博科技有限公司 VIP会员 公司: 北京百奥莱博科技有限公司 联系人:王欣 联系电话: 18518407031 联系邮箱:18518407031@163.com 网站: https://www.bjbalb.com QQ: 570202610 ...
Ataxin-2 (ATXN2)1 is a stress-regulated protein of 124 kDa size, which is expressed in specific neuron populations, but also in hepatocytes (1, 2, 3, 4). The structure of the human ATXN2 protein is characterized (1) by the N-terminal polyQ domain (5), (2) by dispersed proline-...
产品名称Ataxin 2 (ATXN2) Antibody 产品货号Catalogue No: abx124201 产品价格现货询价,电话:010-67529703 产品规格Available Options * Size: 50 µl 100 µl 200 µl 产品品牌abbexa 产品概述 ATXN2抗体是一种抗ATXN2的兔多克隆抗体。