1047635-80-2 Uprosertib 200mg 甲型/乙型双重染料法荧光定量PCR试剂盒 定做种属检测试剂盒 50次 低温 负20度 1047644-62-1 Afuresertib 5mg 甲型/乙型双重RT-PCR试剂盒 定做种属检测试剂盒 50次 低温 负20度 1047644-62-1 Afuresertib 10mg Brucella spp.布鲁氏杆菌属通用可视化LAMP试剂盒 动物病原微生物检测...
(Yi et al., 2013). In SCA3 patients, the clinical safety and efficacy of VPA have also been evaluated; patients treated with 800–1200 mg/day for 12 weeks significantly improved their locomotor function, as assessed by Scale for Assessment and Rating of Ataxia scores (Lei et al., 2016)...
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate Immunohistochemistry (IHC)IHC : 1:50-1:500 Immunofluorescence (IF)-PIF-P : 1:50-1:500 Immunofluorescence (IF)/ICCIF/ICC : 1:450-1:1800 It is recommended that this reagent should be titrated in each testing...
For BioID pull-down prior to mass spectrometry or immunoblot analysis, whole-cell lysates (3 mg protein) prepared from Neuro-2a cells expressing MBI-ataxin-1[85Q] were incubated with streptavidin-agarose (0.05 mL) (Invitrogen). For GFP pull-down prior to mass spectrometry or immunoblot...
1.本发明涉及用于降低动物中的ataxin 3(atxn3)的pre mrna水平、mrna水平和蛋白水平中的至少1种的化合物、使用该化合物的方法、以及含有该化合物的药物组合物。本发明的方法对于治疗、预防atxn3相关疾病、例如脊髓小脑变性症3型(也称为sca3、马查多-约瑟夫病、mjd)或使其进展延缓是有用的。
Phase separated liquid-like droplets of His-FUS LC domain (2 mg/ml) were formed on a cover glass by a quick dilution method (see STAR Methods). Initially, droplets were sinking down on the surface of the cover glass where they fused with other droplets (30 min period). After addition ...
Physical Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1 mg/ml Storage/Stability Store at -20℃/1 year NCBI Gene Symbol ATXN1 Database Links Gene ID: 6310 Swiss-Prot #: P54253 OMIM #: ...
Giunti P, Sabbadini G, Sweeney MG, Davis MB et al (1998) The role of the SCA2 trinucleotide repeat expansion in 89 autosomal dominant cerebellar ataxia families. Frequency, clinical and genetic correlates. Brain 121(Pt 3):459–467. https://doi.org/10.1093/brain/121.3.459 Article PubMed ...
After cervical dislocation, the cerebellum and liver were dissected from homozygous wild-type (Atxn2+/+) and knockout (Atxn2−/−) mice at 6 and 24 weeks of age. Total RNA was extracted from these tissues by homogenization in 1 ml of Trizol® Reagent per 50–100 mg of tissue using...