近日,Cell发表了来自哈佛医学院的Rudolph E. Tanzi 团队题为:Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription的研究成果。研究人员发现Ataxin-1的缺失会降低CIC-ETV4/5对Bace1转录的抑制,导致BACE1表达水平升高,选择性地在阿尔茨海默病易发病的大脑区域增强了APP淀粉...
Ataxin-1,也称为脊髓小脑性共济失调1型蛋白(Sca-1),差异表达并定位于细胞质和细胞核。Ataxin-1突变与常染色体显性神经退行性疾病脊髓小脑性共济失调1型(SCA-1)的发病有关,其特征是小脑进行性神经元缺失、肌肉萎缩和共济失调。在主要观察到SCA-1的浦肯野细胞中,Ataxin-1已被证明与富含亮氨酸的酸性核蛋白(LANP)...
Discover Rockland's Anti-Ataxin 1 (MOUSE) Monoclonal Antibody Fluorescein Conjugated - 200-302-W69, ideal for IHC, IP, WB. Versatile and reliable for various research needs.
Description: Anti-Ataxin 1 (MOUSE) Monoclonal Antibody Peroxidase Conjugated - 200-303-W69 Synonyms: Ataxin-1, ATX1, Atxn1, D6S504E, OTTHUMP00000016065, SCA1, Spinocerebellar ataxia type 1 protein Host Species: Mouse Conjugate: Peroxidase (HRP) Clonality: Monoclonal Format: IgG2b Tar...
研究人员发现Ataxin-1的缺失会降低CIC-ETV4/5对Bace1转录的抑制,导致BACE1表达水平升高,选择性地在阿尔茨海默病易发病的大脑区域增强了APP淀粉样蛋白的切割。BACE1 (beta-site APP cleaving enzyme 1) 表达升高加剧了阿尔茨海默病小鼠模型中Aβ沉积和胶质增生,神经生成和嗅觉轴突靶向功能受损。在脊髓小脑共济失调1型...
中文名称:Anti-phospho-Ataxin 1 antibody-磷酸化脊髓小脑失调症蛋白1抗体 英文名称:phospho-Ataxin 1 (Ser775) 纯度:> 99% 包装信息:50ul/RMB 1280;100ul/RMB 1980;200ul/RMB 2900 备注:Ataxin 1 (phospho Ser776);p-Ataxin 1 (phospho S776); ATX1; ATXN1; SCA1; Ataxin 1; Ataxin-1; Ataxin1; ...
The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two ...
ABP56120共济失调蛋白1 (phospho Ser776) 多克隆抗体Ataxin-1 (phospho Ser776) Polyclonal Antibody ABP50719共济失调蛋白1 多克隆抗体Ataxin-1 Polyclonal Antibody ABP50720共济失调蛋白 多克隆抗体Ataxin-1 (phospho Ser776) Polyclonal Antibody ABP53629共济失调蛋白2样蛋白 多克隆抗体Ataxin-1 Polyclonal Antibody ...
英文名字 ataxin-1 (aa686-699) Antibody (internal region) 供应商 Abgent 产品货号 A-AF3539a 产品报价 ￥2150/0.1mg 产品说明书 点击查看 购买方式 产品新闻 背景资料 Reported variants represent identical protein: NP_001121636.1, NP_000323.2 应用类型 ...
供应产品 ABP56120共济失调蛋白1 (phospho Ser776) 多克隆抗体Ataxin-1 (phospho Ser776) Polyclonal Antibody ABP50719共济失调蛋白1 多克隆抗体Ataxin-1 Polyclonal Antibody 1共1页 推荐产品 我要推广优质信息推广广告 介电常数及介质损耗测试仪生产厂家 德国北宁蓄电池介绍 混凝土快速冻融试验机 冷却塔 ...