Follicular B (FOB) and marginal zone B (MZB) cells are pivotal in humoral immune responses against pathogenic infections. MZB cells can exacerbate endotoxic shock via interleukin-6 secretion. Here we show that the transcriptional repressor capicua (CIC) and its binding partner, ataxin-1-like (...
Observing that the ataxia-associated gene Ataxin-1-like (Atxn1L) was highly expressed in HSCs, we examined its role in HSC function through in vitro and in vivo assays. Mice lacking Atxn1L had greater numbers of HSCs that regenerated the blood more quickly than their wild-type counterparts....
摘要: This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat neurological conditions and to identify compounds that alter IMX97018 polypeptide activities.收藏...
Summary Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative diseases caused by expansion of a polyglutamine tract in the disease prote... YC Lam,AB Bowman,P Jafar-Nejad,... - 《Cell》 被引量: 363发表: 2006年 SCA1-Like Disease in Mice Expressing Wild Type Ataxin-1 ...
1:200-1:400 - 酶联免疫吸附实验 (ELISA) 1:10,000 - 产品规格 种属反应 Human,Mouse,Rat 宿主/亚型 Mouse / IgG1 分类 Monoclonal 类型 Antibody 克隆号 2F5 抗原 Purified recombinant fragment of human ATXN1 expressed in E. Coli. 偶联物 ...
A major consequence of polyQ length is the stabilisation of ataxin-1 protein that leads to higher ataxin-1 levels33; increasing levels of wild-type ataxin-1 can lead to SCA1-like neurodegeneration34,35,36. In the scenario of Pumilio haploinsufficiency, even though many other targets are likely...
ATXN2 is shown to modulate different neurodegenerative diseases like ALS or SCA3 by intermediate repeat length [48]. Both, MW1 and 1C2 polyQ-specific antibodies, are characterized to bind glutamines of different length starting with 11Q but demonstrated higher affinity to longer repeats, because ...
The impact of ataxin-1-like histidine insertions on polyglutamine aggregation Protein Eng. Des. Sel., 22 (2009), pp. 469-478 CrossrefView in ScopusGoogle Scholar [42] B.L. Kagan Amyloidosis and protein folding Science, 307 (2005), pp. 42-43 CrossrefGoogle Scholar [43] H. Jang, J. ...
Finally, like most physiological 14-3-3 binding proteins, Atx1 contains a proline residue at a position two residues C-terminal to the phosphorylated serine. A sharp alteration of the peptide chain direction at this position could change the conformational landscape of the chain and affect the ...
Loss of Pum1 caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels. Breeding Pum1+/− mice to SCA1 mice (Atxn1154Q/+) exacerbated disease progression, whereas breeding them to Atxn1+/− mice normalized Ataxin1 levels...