Here we show that the transcriptional repressor capicua (CIC) and its binding partner, ataxin-1-like (ATXN1L), play important roles in FOB and MZB cell development. CIC deficiency reduces the size of both FOB and MZB cell populations, whereas ATXN1L deficiency specifically affects MZB cells....
英文名称:Ataxin-1 Interacting Ubiquitin-Like Protein (A1Up) Antibody,中文名称:Ataxin-1相互作用泛素样蛋白(A1Up)抗体,产品货号:Catalogue No: abx219229,A1Up抗体是一种抗A1Up的兔多克隆抗体。目标A1Up反应性人、小鼠、大鼠宿主兔克隆
摘要: This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat neurological conditions and to identify compounds that alter IMX97018 polypeptide activities.收藏...
Observing that the ataxia-associated gene Ataxin-1-like (Atxn1L) was highly expressed in HSCs, we examined its role in HSC function through in vitro and in vivo assays. Mice lacking Atxn1L had greater numbers of HSCs that regenerated the blood more quickly than their wild-type counterparts....
A major consequence of polyQ length is the stabilisation of ataxin-1 protein that leads to higher ataxin-1 levels33; increasing levels of wild-type ataxin-1 can lead to SCA1-like neurodegeneration34,35,36. In the scenario of Pumilio haploinsufficiency, even though many other targets are likely...
英文名称:Ataxin 7 Like 1 (ATXN7L1) Antibody (FITC),中文名称:Ataxin 7样1(ATXN7L1)抗体(FITC),产品货号:Catalogue No: abx312253,ATXN7L1抗体(FITC)是一种兔抗ATXN7L1的多克隆抗体,与FITC结合。目标ATXN7L1反应性人宿主兔克隆性多
Importantly, the remarkably spherical appearance of the ataxin-1[85Q] NBs (Fig. 1A, upper panel) raises the possibility that these NBs arise from phase separation of the ataxin-1[85Q] protein. Phase separation is a phenomenon that gives rise to membrane-less liquid-like compartments that are...
kl966Hu02 唾液酸结合Ig样凝集素1(SIGLEC1)多克隆抗体 Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) kl171Ga01 转铁蛋白受体(TFR)多克隆抗体 Polyclonal Antibody to Transferrin Receptor (TFR) 标题: 内容: 联系人: 联系电话: ...
SUMOylation of the Polyglutamine Repeat Protein, Ataxin-1, Is Dependent on a Functional Nuclear Localization Signal SUMO (small ubiquitin-like modifier) is a member of the ubiquitin family of proteins. SUMO targets include proteins involved in numerous roles including nu... BE Riley,HY Zoghbi,HT...
Ataxin-3 like immunoreactivity was observed in all human brain regions and peripheral organs studied. In neuronal cells of control individuals, ataxin-3c was expressed cytoplasmatically and had a somatodendritic and axonal distribution. In SCA3 patients, however, C-terminal ataxin-3c antibodies as ...