此外,亮氨酰-tRNA合成酶 (LRS) 是 mTORC1 信号转导的另一个亮氨酸传感器。LRS 被转位到溶酶体,在那里它作为 GAP 促进 RagC/D 的 GTP 水解形成 GDP-RagC/D,从而导致 mTORC1 活化(图3)。因此,LRS 通过 mTORC1 信号通路功能性地调节自噬 。值得注意的是,亮氨酸对 mTORC1 的影响比其他氨基酸强得多。单独...
Kawai G, Yamamoto Y, Kamimura T, Masegi T, Sekine M, Hata T, Iimori T, Watanabe T, Miyazawa T, Yokoyama S (1992) Conformational rigidity of specific pyrimidine residues in tRNA arises from posttranscriptional modifications that enhance steric interaction between the base and the 2’-hydroxyl ...
RNA sequences, where the alphabet is {A, C, G, U}, ranging from ~50 characters for tRNA to thousands for mRNA. Proteins, where the alphabet is made of 22 amino acids, ranging from 2 characters for dipeptide to 35,000 for Titin, the longest protein.The...
Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand. eLife 7, e39518 (2018). Article PubMed PubMed Central Google Scholar Hildebrandt, L. L., Preus, S. & Birkedal, V. Quantitative single molecule FRET efficiencies using TIRF microscopy. ...
Amino Acid Derivatives EAAT EAAT相关产品(11) 货号产品名中文名称产品描述 SJ-MB0015 Evans Blue 埃文斯蓝;伊文思蓝 Evans Blue (Direct Blue 53) 是一种通过膜结合兴奋性氨基酸转运蛋白 (EAAT) 摄取 L-谷氨酸的有效抑制剂。Evans Blue 是一种 L-谷氨酸 (L-glutamate) 和红藻氨酸受体 (kainate receptor) ...
If amino acids are oversupplied What food source contains all the essential amino acids? What amino acid is involved in osteogenesis imperfecta? Which region of a tRNA molecule binds to amino acids? What is the amino acid to be carried by this tRNA? It is a three-letter word like Phe. ...
For these purposes, the Ser286 codon (AGT) was replaced by an amber stop codon (TAG) within the luciferase gene and transformed into Escherichia coli strains producing specific amber suppressor tRNA's to express luciferase with different substitutions at this position.Tuncer Arslan...
F. Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA. J. Mol. Biol. 211, 135–145 (1990). Article CAS Google Scholar Lee, K., Varma, S., SantaLucia, J. J & Cunningham, P. R. In vivo determination of RNA structure–...
Amino acid substitutions at position 73 in motif 2 of Escherichia coli alanyl-tRNA synthetase. Lysine73, located in the adenylate synthesis domain of Escherichia coli alanyl-tRNA synthetase (AlaRS), was previously indicated to be an important residue... SJ Filley,KAW Hill - 《Archives of ...
Using CoA, which carries two potentially reactive groups -SH and -OH, as a model compound we showed that at high pressure amino acid is bound preferentially to the hydroxyl group of the terminal ribose ring.关键词: high pressure non-natural amino acids tRNA charging ...