36,37. We reasoned that the hexameric complex that assembled in response to Ni2+could nucleate further assembly, because each incoming dimer will make two contacts to the nucleating hexamer, only one of which was compromised by the Y132A mutation. Thus, the Y132A may weaken the...
Upon activation and before cell division, expression of the transcription factor c-Myc drives metabolic reprogramming, necessary for the subsequent proliferative burst3. Here we find that during the first division of an activated T cell in mice, c-Myc can sort asymmetrically. Asymmetric distribution ...
An asymmetry in the lipid composition between the monolayers of the plasma membrane is now recognized as an important factor of membrane functioning. The composition of the membrane leaflets is highly uneven13,23,24and is actively maintained by a group of proteins – the flippases and floppases....