1.Studies on the influencing factors on compound metformin-glipizide bilayer sustained-release tablets using the similarity factor;采用相似因子法评价不同因素对复方二甲双胍格列吡嗪双层缓释片体外释放的影响 2.The release conditions in vitro were investigated by a similarity factor method.方法:以PEO,HPMC,...
In this regard, mobile phase ratio, flow rate, and pH were simultaneously changed, and capacity factor, total analysis time, and resolution were considered as responses. To validate the method, the key parameters of the method were determined and used for all the validation steps. Therefore, ...
The good relationship module reflecting molecular structure, solvent strength and capacity factor was established. Molecular similarity method was successfully used to predict capacity factors (k') and the validation results of 7 drugs were satisfactory. The correlation coefficient of test samples was ...
One novel venom factor was isolated and purified from the venom of Taiwan habu (Trimeresurus mucrosquamatus) using two consecutive anion-exchange and gel-filtration chromatographies followed by cation-exchange HPLC. Further characterization of the purified protein indicated that it lacks the proteolytic ...
where λ = δ2 now serves as a scaling factor balancing the influences of p(b m |w) and p(w). Put it differently, λ determines how much influence the covariance matrix has at each residue position. The optimal λ is determined by minimizing the cross-validated distance shown below: Her...
It converts prothrombin to thrombin by cleaving both the peptide bonds Arg274– Thr275and Arg323– Ile324,similar to mammalian factor Xa. It is a protein complex (250 Kd) consisting of an enzymatic and a nonenzymatic subunit. These subunits were separated by reverse phase HPLC and their ...
Unanticipated PTM features in the plasma protein properdin We next studied the plasma protein properdin, also named as Factor P36,37, representing one class of important glycoproteins. Properdin is a member of the complement protein family and plays a critical role during complement activation38. It...
Thus, RagA and RagBs appear to exchange bound GTPγS in the absence of any catalyzing factor. GTPase activity of Rag was tested by loading of the protein with [α-32P]GTP. After an additional incubation period of 0-60 min, the bound tracer nucleotides were separated by thin-layer ...
Infliximab RP is a chimeric immunoglobulin G (IgG) monoclonal antibody (mAb) produced in murine myeloma cells by recombinant DNA technology. The primary mechanism of action of infliximab RP is to neutralize the biological activity of tumor necrosis factor-alpha (TNFα) by binding with high ...
The similar factor was 81. 方法桨法,蒸馏水为溶出介质,用HPLC检测,计算累积溶出百分率,提取溶出参数(T50,Td,m)进行统计分析,并采用相似因子法评价试验药品和进口对照药品溶出度的相似程度。5) similarity factor 相似因子法 1. Method In this study,the metformin hydrochloride sustained-release tablets were...