Cornell-Bell, A. H. and Williamson, A. ( 1993 ) Hyperexcitability of neurons and astrocytes in epileptic human cortex . In: Biology and Pathology of Astrocyte-Neuron Interactions . S.Federoff , B. H. J.Juurlink , and R.Doucette , eds. Plenum Press, New York , pp. 51 – 65 ....
These calcium peaks are responsible for astrocyte-to-astrocyte and astrocyte-to-neuron communication. They occur (1) as intrinsic oscillations resulting from release of calcium stored in the cell (spontaneous excitation), or (2) peaks induced by transmitters released by neurons. In the latter case...
In general, astrocytes resist ischaemic attacks better than neurones. Oxygen-glucose deprivation in cell cultures kills all neurones within an hour, whereas astrocytes survive for several hours more.202,203In vivo, astrocytes are more sensitive to periods of ischaemia, although they still tolerate th...
Future investigations of the intimate neuron-astrocyte partnership will require stringent and novel methodologies. This timely book on methodological approaches for studying astrocytes will provide modern neuroscientists with indispensable technical advice to help unravel the mysteries of the beautiful and ...
these studies provide important proof-of-concept that human stem cell derived neural derivatives can be used effectively to model neuron–astrocyte interactions and investigate their mechanism. In the endeavour for clinically translatable interventions that may abate the course of neurodegenerative disorders,...
Recent research has highlighted the astrocyte’s involvement in neuroinflammation and oxidative stress in AD [24], the beneficial and detrimental aspects of astrocyte reactivity in AD pathophysiology [25], the astrocytic-amyloid relationship [26], and the importance of astrocyte-neuron interactions in ...
Acute treatment with 17beta-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication. Astrocytes are now recognized as dynamic signaling elements in the brain. Bidirectional communication between neurons and astrocytes involves integration o... SP Rao,SK Sikdar - 《Glia》 被引量: 18发...
The most frequent cell in the SL, here termed an amphomorphic cell (AC), has a mixed astrocyte–neuron phenotype. Although each AC exhibits four sets of processes or domains, variation in the complexity of these domains justified dividing them into six subclasses that might correspond to ...
However, the neuron-astrocyte interaction has been largely limited to the tripartite synapse or neuronal pre- and postsynaptic elements and surrounding astrocytes (Araque et al., 1999, Halassa et al., 2007, Perea et al., 2009). Astrocytic calcium signals can be transmitted through branched ...
Connexin32 like immunoreactivity( LI) and connexin43 LI appeared in the neuron side and astrocyte side, respectively. In the experimental group this ultrastructure was increased notably compared with the control. We considered that the newly found ultrastructure might be an isogenous structure of gap ...