Previous work has demonstrated that alteration of AHR signaling perturbs murine development of both T lymphocytes and vascular structure. Due to their common hemangioblast-lineage, vascular and immune cell types share several key features which may include similar AHR-regulated pathways. This thesis ...
Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem. Biophys. Res. Commun. 375, 331–335 (2008). CAS PubMed PubMed Central Google Scholar Benson, J. M. & Shepherd, D. M. Dietary ligands of the aryl hydrocarbon receptor induce anti-inflammatory and...
Di Meglio et al. (2014) show that the environment-responsive transcription factor AhR acts in keratinocytes to suppress psoriatic lesions.doi:10.1111/jdv.15148Merk H.F.Journal of the European Academy of Dermatology and Venereology
et al. Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells. PLoS One 11, e0167650 (2016). Article PubMed PubMed Central Google Scholar Yan, J. et al. Aryl hydrocarbon receptor signaling prevents activation of hepatic stellate cells and liver ...
Aryl hydrocarbon receptor Aryl hydrocarbon receptor Identifiers Symbol(s) AHR; External IDs OMIM: 600253 MGI: 105043 Homologene: 1224 Gene
The AHR/ARNT complex is in turn regulated by hypoxia-inducible-factor-1α (HIF-1α) and the aryl-hydrocarbon receptor-repressor (AHRR). In this study we investigated whether altered AHR signalling underlies defective CD39 expression and function in AIH Treg and Th17-cells, therefore contributing...
Infection by antibiotic-resistant microorganisms is common in intensive care units and has become a global problem. Here, we determined the effect of aryl hydrocarbon receptor (AhR) stimulation on antibiotics-induced systemic defense impairment and its m
AhR signaling in ECs but not T cells governed the increased number of Tregs and their localization in the colon. Our findings provide evidence that AhR signaling in ECs increases Tregs, with alterations in their transcriptomic profiles and localization. Results IN increases Helios+ Tregs in the ...
Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription fa...
Zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components affecting intestinal epithelial barrier function. Here, we explore whether zinc and the AHR pathway are linked. We show that dietary supplementation with an AHR