This review provides data suggesting that ligands for the AhR are selective AhR modulators (SAhRMs) that exhibit tissue/cell-specific AhR agonist and antagonist activities, and that their functional diversity is similar to selective receptor modulators that target steroid hormone and other nuclear ...
aConfiguration Examples 配置例子[translate] aNatural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles 小肠淋巴腺滤泡自然芳香族羟基的碳氢化合物感受器官Ligands控制器官形成[translate]
Kynurenine and some of its metabolites act as aryl hydrocarbon receptor (AHR) ligands and exert important functions in the immune system in inflammatory, infectious and neoplastic disorders. T regulatory type 1 cells (TR1 cells). A population of regulatory T cells that arises in the periphery ...
H. Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat. Rev. Cancer 14, 801–814 (2014). Article CAS PubMed PubMed Central Google Scholar Liu, Y. et al. Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation. ...
"Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine". J. Biol. Chem. 276 (34): 31475–8. doi:10.1074/jbc.C100238200. PMID 11425848. ^ Sinal CJ, Bend JR (1997). "Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma...
Infection by antibiotic-resistant microorganisms is common in intensive care units and has become a global problem. Here, we determined the effect of aryl hydrocarbon receptor (AhR) stimulation on antibiotics-induced systemic defense impairment and its m
1. Sediment extracts from 63 European remote lakes were tested for the presence of ligands of the aryl hydrocarbon receptor (AhR), using a yeast-based bioassay. The lakes belong to different European mountain regions in Central Norway, Scotland, Piedmont (Italy), Tyrol (Austria and Italy) and...
AhR KO mice challenged with inhaled endotoxin, which does not contain AhR ligands, also developed greater lung neutrophilia than controls, and bronchoalveolar lavage cells from AhR KO mice produced elevated levels of tumor necrosis factor-α and interleukin-6 when treated with endotoxin in vitro. ...
Exogenous synthetic ligands AhR ligands have varying levels of affinity and reactivity. To date, the majority of high-affinity AhR ligands are synthetic ligands, which are formed as a result of non-biological activity and include environmental contaminants, such as halogenated aromatic hydrocarbon (HAH...
Zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components affecting intestinal epithelial barrier function. Here, we explore whether zinc and the AHR pathway are linked. We show that dietary supplementation with an AHR pre-ligand offers protection against inflammatory...