This review provides data suggesting that ligands for the AhR are selective AhR modulators (SAhRMs) that exhibit tissue/cell-specific AhR agonist and antagonist activities, and that their functional diversity is similar to selective receptor modulators that target steroid hormone and other nuclear ...
Kynurenine and some of its metabolites act as aryl hydrocarbon receptor (AHR) ligands and exert important functions in the immune system in inflammatory, infectious and neoplastic disorders. T regulatory type 1 cells (TR1 cells). A population of regulatory T cells that arises in the periphery ...
Infection by antibiotic-resistant microorganisms is common in intensive care units and has become a global problem. Here, we determined the effect of aryl hydrocarbon receptor (AhR) stimulation on antibiotics-induced systemic defense impairment and its m
The aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) tran- scription factor family that is well-known to mediate the toxicological responses of environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Other ligands for ...
facilitating its translocation into the nucleus. Numerous transcription factors are activated by AhR upon binding to unknown ligands. Arachidonic acid, pyrene, tryptophan, and flavonoid derivatives are low-affinity endogenous ligands that can also activate the AhR. Halogenated aromatic hydrocarbons (HAHs) ...
AhR signaling pathway. Before ligand binding, AhR remains stable in the cytoplasm within the HSP90/XAP2/p23 complex. When exposed to AhR ligands, such as uremic toxins, pollutants or natural plants, AhR changes its conformation, thus exposing the nuclear localization sequence in its N-terminal ...
Aryl hydrocarbon receptor Aryl hydrocarbon receptor Identifiers Symbol(s) AHR; External IDs OMIM: 600253 MGI: 105043 Homologene: 1224 Gene
Furthermore, the effect of AIP knockdown on GH3 secretion in the presence of AhR ligands was inconclusive (85, 86). The functional effects of the AIP-NME1 interaction remain unknown (84). More work is needed to understand how AIP mutations impact its interactions with other proteins and the...
Indole scaffolds as a promising class of the aryl hydrocarbon receptor ligands ZdeněkDvořák, ...SridharMani, inEuropean Journal of Medicinal Chemistry, 2021 1Aryl hydrocarbon receptor AhR Thearyl hydrocarbon receptor(AhR) was discovered in the early 70s′ as the first xenosenso...
AhR ligands have varying levels of affinity and reactivity. To date, the majority of high-affinity AhR ligands are synthetic ligands, which are formed as a result of non-biological activity and include environmental contaminants, such as halogenated aromatic hydrocarbon (HAH) and polycyclic aromatic ...