Our study describes AhR regulated transcriptional responses in human primary trophoblast by using the AhR agonist, 尾-naphthoflavone (BNF). Human primary trophoblast cells were isolated from full term placenta after delivery. The trophoblasts were exposed to 25 M of AhR agonist, BNF, for 72 ...
Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunityLow-grade chronic inflammation in visceral adipose tissue and the intestines are important drivers of obesity associated insulin resistance. Bioactive compounds...
以后再请检查。 [translate] aRecurrent early-stage triple-negative breast cancer. 正在翻译,请等待... [translate] aBreast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist. 乳腺癌词根象细胞由一个无毒芳香族羟基的碳氢化合物感受器官苦闷者禁止。 [translate] ...
et al. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Mol. Pharmacol. 85, 777–788 (2014). PubMed PubMed Central Google Scholar Takamura, T. et al. Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran...
We have shown that environmental chemicals, such as aromatic hydrocarbon receptor (AhR) agonists, suppress B lymphopoiesis by modulating bone marrow stromal cell function. Here, we extend these studies to evaluate the potential for two prototypic AhR agonists, 7,12-dimethylbenz [a]anthracene (DMBA)...
No.: HY-104026CAS No.: 2922-83-0分式: CHNO分量: 208.21作靶点: Aryl Hydrocarbon Receptor; Endogenous Metabolite作通路: Immunology/Inflammation; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (240.14 mM;...
The aryl hydrocarbon receptor (AhR), a member of the PAS protein family, is found in organisms as diverse as Drosophila melanogaster, nematodes, and mammals. While several reviews have reported that AhR, once activated by agonist ligands, causes long-term effects such as modification of cell ...
A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo Arch Biochem Biophys, 450 (2006), pp. 67-77 View PDFView articleGoogle Scholar Cited by (155) Kynurenic Acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and it...
The Aryl hydrocarbon receptor (AhR) is a member of the family of basic-helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
Zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components affecting intestinal epithelial barrier function. Here, we explore whether zinc and the AHR pathway are linked. We show that dietary supplementation with an AHR