The position of immobilization is not as critical in the upper extremities because they contain primarily non–weight-bearing joints. The effects of immobilization on articular cartilage can be separated into contact and noncontact effects. In contact areas, the seriousness of the changes depends ...
Dean DD, Woessner JF. Extracts of human articu- lar cartilage contain an inhibitor of tissue metalloproteinases. Biochem J 1984;218:277-80.Dean DD, Woessner JF Jr: Extracts of human articular cartilage contain an inhibitor of tissue metalloproteinases. Biochem J 218: 277-280, 1984...
MRI or CT delineate patellofemoral morphologic features (including the extent of dysplasia), evaluate congruity of the patella in the trochlea, and provide objective measurement of the TT-TG distance and patellar height, with the understanding that cartilage contour does not always match bone contour....
Using LM it was not possible to determine what these structures were or to gain any detailed knowledge of their ultrastructure. Further analysis of AKU and WT with TEM also revealed the presence of these concentric ring structures and led to a more robust analysis of the cartilage to try and...
(C). Although the cartilage can be imaged before and during loading, the measurement of nominal measures does not provide internal information and there is insufficient image texture for digital image correlation techniques. Because dualMRI is based on phase contrast, internal displacements can be ...
Articular cartilage defects in the knee have poor intrinsic healing capacity and may lead to functional disability and osteoarthritis (OA). “Instant MSC Product accompanying Autologous Chondron Transplantation” (IMPACT) combines rapidly isolated recycled autologous chondrons with allogeneic MSCs in a one...
cartilage, specifically when inflammation is primary in the cause of cartilage damage, as in the case for rheumatoid arthritis.” However, in OA, in which inflammation may contribute to but is not primarily responsible for cartilage damage, adverse direct effect...
PLTs contain granules with abundant growth factors, which have roles in angiogenesis, tissue regeneration, chondrocyte proliferation, and cartilage matrix secretion [17], while also reducing the catabolic effect of interleukins which play a role in OA [18]. In various studies, PRP has been ...
NLK is therefore a candidate factor that can be applied in the treatment of cartilage defects. Articular cartilage injury or loss is common in the department of orthopaedics, while therapeutic out- come is not always satisfactory, mainly due to poor self-regeneration of articular chondrocytes1. ...
In an attempt to reverse the breakdown of the extracellular matrix, chondrocytes increase synthesis of matrix components including proteoglycans. Even though this activity increases, a net loss of proteoglycans in the upper cartilage layer is seen. Elevated anti-inflammatory cytokines found in the synovi...