Quantifying Articular Cartilage Tissue Functionality by Multiparametric Quantitative MRI to Identify Early Degenerationdoi:10.1055/s-0039-1687702Nebelung, SvenPost, ManuelKuhl, ChristianeTruhn, DanielThieme Medical PublishersSeminars in Musculoskeletal Radiology...
Which tissue in the body makes blood,bones and cartilage? In what structure is red bone marrow located within long bones of an adult? a) Epiphyseal line b) Periosteum c) Medullary cavity d) Epiphysis e) Articular cartilage 1. Describe sutures and fontanel...
One week after intra-articular injection of mBSA (day 28), mice were sacrificed, and joints were either used for immunohistochemistry or scRNA-seq. For assessment of the degree of arthritis, joints were routinely fixed in 4% paraformaldehyde (PFA), decalcified in formic acid/sodium citrate ...
Immunohistochemical staining of the DOT1L protein in mouse limbs supports a role for DOT1L in chondrogenic differentiation and adult articular cartilage. DOT1L is also expressed in OA articular chondrocytes. Silencing of Dotil inhibited chondrogenesis in vitro. Dot1l knockdown reduces proteoglycan and ...
Further analyses via a protein-protein interaction (PPI) network identified two hub lncRNAs, CRNDE and LINC00152, involved in the process of age-related degeneration of articular cartilage. Our findings suggest that lncRNAs may play active roles in the development of OA. Investigation of the gene ...
An increasing line of evidence suggests that there are strong inter-relationships between the subchondral bone and the articular cartilage [1]. At present it is neither well-documented nor understood which parameters are initiators or drivers of the disease. For the majority of patients, the ...
Martin, J.A., et al., The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair. J. Bone Joint Surg. Am., 85-A Suppl. 2:106-110 (2003). Ruiz-Romero, C., et al., Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes An...
The OCT images were then compared to their corresponding histology, using non-polarized and polarized light microscopy, in order to evaluate the usefulness and structural clarity of the images. In the OCT images we were able to identify the superficial layer of the articular cartilage, the ...
articular cartilagematrix metalloproteinase-9chondrocytessynovial fluid cellsThis article looks at the constraining influence of internal organizational factors on the management of organizational change. The purpose of the study was to determine the individual and group behavioral-induced situational problems, ...
We investigated for the first time zonal-dependent water distribution in articular cartilage by Raman spectroscopy (RS). We further investigated the association of histopathologic score with RS- and magnetic resonance imaging (MRI)-based water measurements. Cadaveric human cartilage plugs (N=16) with ...