A former city police officer admitted on Thursday that he took favors and money from a Queens brothel as part of a protection scheme that helped shut down its competitors. The former officer, Dennis Kim, 31, pleaded guilty in United States District Court in Brooklyn to a federal charge of ...
They hydrolyze the terminal guanidinium moiety of peptidyl Arg into peptidyl citrulline residue, altering the surface charges on the protein surface. PADs have a wide range of tissue distribution and play a role in many physiological processes. PAD2 and PAD4 are in general associated with neuronal...
Net charge of -3-3 at pH 7 and with the amino acids arginine15 or arginine15-alanine17 in the binding region; serine protease inhibitorsdoi:US20030096752 A1The present invention relates to aprotinin variants having improved enzyme-inhibitory, immunological and pharmacokinetic properties and their ...
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It has been reported that R236 is located in the catalytic center of PHGDH and is responsible for PHGDH activity, likely due to its positive charge property that anchors the carboxyl group of 3-PG52. To this end, mutation of arginine to a negatively charged glutamate (R236E), which indeed...
Optimal solution conditions for arginine viral inactivation found in the literature are high arginine concentrations (0.7M), a time of 60 minutes, and a synergistic factor of high temperature (>40°C), low pH (<pH 4), or Tris buffer (5 mM). However, at optimal conditions full inactivation...
The protein charge envelope was averaged across the corresponding protein elution peaks and deconvoluted into the uncharged form using the Protein Deconvolution program provided by the manufacturer. To identify GlcNAcylated arginine and arginine-containing peptides, the chymotrypsin or trypsin-digested Rab...
Histones have numerous terminal tails made up of basic (positively charged) amino acids arginine and lysine while DNA is a macro-anion which holds one negative charge per phosphate moiety all along the double-helix. As a first attempt, in this study, the complexity of the nuclear chromatin ...
As the starting ionic strength of the buffers used here is very low, the addition of ionic compounds, such as arginine salts, is expected to screen the electrostatic repulsion between PPI13 molecules bearing overall positive charge at pH 5.0 and 6.5, and partially screen intramolecular Coulomb ...
77 To neutralize the system’s charge, Na+ ions were added. The equilibration of the systems was carried out using the NPT ensemble following the default Desmond protocol, which involved a total of eight steps. The first seven steps were short simulations that gradually increased the temperature...