chains the charge of arginine side-chains is relatively unaffected by the surrounding environment.1'1 As a consequence, arginine provides nature with a reliable means of placing a positive charge at any required position in a bio-molecule, such as in active sites or at protein-ligand interfaces...
Arginine side-chains play a distinct role because of their high pKa and perpetual positive charge. An NMR method is presented, based on carbon-detected 13Cζ–15Nε correlation spectra, which allows probing the arginine side-chains and their dynamics at neutral-to-high pH. The methodology is ...
Arginine side‐chains play a distinct role because of their high pKa and perpetual positive charge. An NMR method is presented, based on carbon‐detected 13Cζ–15Nε correlation spectra, which allows probing the arginine side‐chains and their dynamics at neutral‐to‐high pH. The methodology ...
They hydrolyze the terminal guanidinium moiety of peptidyl Arg into peptidyl citrulline residue, altering the surface charges on the protein surface. PADs have a wide range of tissue distribution and play a role in many physiological processes. PAD2 and PAD4 are in general associated with neuronal...
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having negatively charged head groups, to mimic electrostatic properties of the plasma membrane characterized by a slight prevalence of a negative charge. One of the popular model membranes is 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) with addition of a small amount of 1,2-...
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It has been reported that R236 is located in the catalytic center of PHGDH and is responsible for PHGDH activity, likely due to its positive charge property that anchors the carboxyl group of 3-PG52. To this end, mutation of arginine to a negatively charged glutamate (R236E), which indeed...
However, despite both arginine and lysine being positively charged at physiological pH, there are notable differences in the roles of the two amino acids. In our simulations, phase-separated condensates of the protein RmK50−m, where m∈Z is varied between 0 and 50, mixed with a charge-...
The protein charge envelope was averaged across the corresponding protein elution peaks and deconvoluted into the uncharged form using the Protein Deconvolution program provided by the manufacturer. To identify GlcNAcylated arginine and arginine-containing peptides, the chymotrypsin or trypsin-digested Rab...