The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid. Redox Signal. 11, 497-508.Calkins MJ, Johnson DA, Townsend JA, Vargas MR, Dowell JA, Williamson TP, Kraft AD, Lee JM, Li J, and Johnson JA. The Nrf2=ARE pathway as a potential thera- peutic...
The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro. Environ Toxicol. 2016;31(11):1439-1449.The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo (a)pyrene-Induced HTR cells damages in vitro. Dong Q,Hou H,Wu ...
The Nrf2/ARE pathway: A promising target to counteract mitochondrial dysfunction in Parkinson's disease. Parkinsons Dis 2011;2011:314082.K.U. Tufekci, E. Civi Bayin, S. Genc, K. Genc, The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease, ...
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The nuclear Nrf2 protein expressions were upregulated as well as the downstream mRNA expressions of HO-1 and NQO1 in a dose-dependent manner. In addition, the proteins expression of PKC and CKII was also increased significantly even at 1???M. The results suggested that Nrf2/ARE pathway is ...
【目的】探讨激活核因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)通路改善尿毒症患者血清诱导的内皮细胞功能障碍的作用及其机制。【方法】体外培养人主动脉内皮细胞,分别与10%正常人血清、10%非糖尿病尿毒症患者血清及10%糖尿病尿毒症患者血清共培养,同时用20 μmol/L叔丁基对苯二酚(tBHQ)预处理人主动脉内皮细胞4 ...
Natural products Cancer prevention Nrf2–ARE pathway Tumorigenesis Dietary phytochemicals 1. Introduction Tumorigenesis is a multiple-stage and multiple-factor process, typically divided into three stages, including initiation, promotion and progression [1]. Despite extensive global research aimed at ameliorat...
Here we summarize the dual effects of flavonoids in cancer chemoprevention and cancer promotion with respect to the regulation of the Nrf2/ARE pathway, while underlying the possible cellular mechanisms. Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the...
Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mito...
The present study aimed to evaluate the protective efficacy of testosterone propionate (TP) on age-related liver changes via activation of the nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway in aged rats. Aged