To maintain the balance between bioactivation and detoxification, living cells maintain an inducible antioxidant response pathway, which activity is largely regulated by nuclear factor erythroid-2-related factor 2 (Nrf2). Nrf2 governs the expression of many detoxification enzymes and antioxidants and acts...
已经有超过500个基因被确认是通过Nrf2/ARE通路被SFN激活的，这很可能低估了正在被发现的其他基因的数量。大量的细胞保护基因被上调，包括编码内源性酶和非酶抗氧化剂以及II相解毒酶。Nrf2在协调诱导那些编码许多应激反应和细胞保护酶及相关蛋白的基因中起着关键作用。包括NAD（P）H：醌还原酶1（NQO1）、血氧合酶1...
增多Nrf2通过其上的NLS游离至核内,与小Mafs蛋白形成异二聚体,并协同转录因子CBP与抗氧化反应元件ARE结合,启动Nrf2/ARE信号通路,上调ARE调控的抗氧化酶及二相解毒酶基因表达,增加细胞对氧化应激的抗性,达到清除自由基的目的[9,11,12,14]。 当细胞恢复正常时,Keap1进入核内,与核内Nrf2形成Nrf2-Keap1复合物,并通...
Kunsch, “Induction of Cytoprotective Genes Through Nrf2 / Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflflammatory Diseases,” Current Pharmaceutical Design, vol. 10, no. 8, pp. 879–891, 2004. [2] R. Hu, C. Xu, G. Shen et al., “Gene ...
The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro. Environ Toxicol. 2016;31(11):1439-1449.The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo (a)pyrene-Induced HTR cells damages in vitro. Dong Q,Hou H,Wu ...
Nuclear factor-erythroid 2-related factor-2 (Nrf2) can activate cellular protection against oxidative stresses and inhibit inflammatory response. Nrf2/ARE signaling pathway can attenuate several inflammatory diseases, including inflammatory bowel disease (IBD). IBD is one of the most difficult points in...
DOI :https://doi.org/10.1093/abbs/gmaa013 Article index updated : Feb 15, 2025 Altmetric score(what's this?) 8 CITATIONS 8 Crossref 7 Web of Science Source article Related records 7 Scopus 1092 Article access Explanation of terms and methodology ...
核细胞因子 Nrf2 ( nuclear factor erythroid 2⁃related factor 2) 和它的胞质接头蛋白 Keap1 ( kelch⁃like ECH⁃associated protein1) 是细胞抗氧化反 应的中枢调节者,Nrf2 通过与抗氧化反 应元件 ( antioxidant response element, ARE) 相互作用,诱导编码抗氧化酶和Ⅱ 相解毒酶 的表达, 在细胞的防御...
Genc, K. Genc, The Nrf2/ARE pathway: a prom- ising target to counteract mitochondrial dysfunction in Parkinson's disease, Parkinson's Dis. 2011 (2011) 314082.Tufekci K U, Civi Bayin E, Genc S, et al. The Nrf2/ ARE pathway: a promising target to counteract mitochondrial dysfunction in ...
Brain cancer is regarded as one of the most life-threatening forms of cancer worldwide. Oxidative stress acts to derange normal brain homeostasis, thus is involved in carcinogenesis in brain. The Nrf2/Keap1/ARE pathway is an important signaling cascade r