Two intramolecular isopeptide bonds are identified in the crystal structure of the Streptococcus gordonii SspB C-terminal domain. J. Mol. Biol., 397, 740-751.Forsgren N, Lamont RJ, Persson K. Two intramolecular isopeptide bonds are identified in the crystal structure of the streptococcus ...
Here, we show how changes in hydration structure microscopically correlate with large-amplitude motions of a multi-domain protein, through molecular dynamics simulation supported by structural analyses and biochemical experiments. We first identified collective domain motions of the protein, which open/...
One of the fundamental questions about human language is whether all languages are equally complex. Here, we approach this question from an information-theoretic perspective. We present a large scale quantitative cross-linguistic analysis of written language by training a language model on more than ...
Figure 2. The Asymmetric Unit in the Crystal Structure of Ral-GppNHP GppNHp is in cyan, Mg2+ is in yellow, and the coordinating water molecules are in red. A further unusual feature in this region is the presence of a second Mg2+ ion coordinated to the γ-phosphate of the nucleotide (...
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Protein phosphatase 2A (PP2A) is a principal Ser/Thr phosphatase, the deregulation of which is associated with multiple human cancers, Alzheimer's disease ... Cho, US,Xu, WQ - 《Nature》 被引量: 544发表: 2007年 PP2A: ...
Add multiple location paths into the web.config Add new column in existing CSV file using C# Add query string when user clicks back button Add Reference Issue Add rows to a Table in run time , one by one Add Trusted Site in the IIS server Adding .ASHX files to an existing Project......
GK belongs to a family of amino acid kinases, and a predicted three-dimensional model of this enzyme was constructed on the basis of the crystal structures of three related kinases. In the model, residues that were identified as important for allosteric control were located close to each other...
Theoretical bounds on the influence of solute conformation on DeltaG are inferred by considering the hydration of idealized linear (all-trans) and globular (spherical) model solutes. More detailed theoretical extrapolations of experimental and simulation results imply that the water-mediated free energy...
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in
The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remains elusive. Here, we have screened for regulators of PRKN-independent mitophagy using an siRNA library targeting 197 proteins containing lipid interacting domains. We identify Cyclin G-associated kinase (GAK...