Here, we show how changes in hydration structure microscopically correlate with large-amplitude motions of a multi-domain protein, through molecular dynamics simulation supported by structural analyses and biochemical experiments. We first identified collective domain motions of the protein, which open/...
One of the fundamental questions about human language is whether all languages are equally complex. Here, we approach this question from an information-theoretic perspective. We present a large scale quantitative cross-linguistic analysis of written language by training a language model on more than ...
What physical properties are determined by a mineral's crystal structure? What are the types of native element minerals? Is oxygen a mineral? Is corundum an oxide mineral? Is orthoclase an oxide mineral? Are borates a class of mineral?
We identified two phage peptides that share sequence homologies with EBV nuclear antigens 1 and 2 (EBNA1 and EBNA2), respectively. The specificity of the EBV epitopes found by panning with MS brain IgG was confirmed by ELISA and competitive inhibition assays. Using a highly sensitive phage-...
CRYSTAL-STRUCTURETETRAHYMENA RIBOZYMETERTIARY STRUCTUREWe present a simple approach to locate sites that undergo conformational changes upon crystallization by comparative structural mapping of the same RNA in three different environments. As a proof of principle, we probed the readily crystallized P4-P6 ...
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Protein phosphatase 2A (PP2A) is a principal Ser/Thr phosphatase, the deregulation of which is associated with multiple human cancers, Alzheimer's disease ... Cho, US,Xu, WQ - 《Nature》 被引量: 544发表: 2007年 PP2A: ...
Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-contai... We have determined the crystal structures of the ligand binding domain (LBD) of the rat vitamin D receptor in ternary complexes with a ...
6A). In the structure of PS II from T. elongatus, a different Ca2+ site in PsbO has been identified (4, 5, 68), not found in the T. vulcanus crystals. All these Ca2+ sites are located on the lumenal/donor side of PS II in the subunit CP47, the cytochrome b559 subunit β (...
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in
Chiral active particles (CAPs) are self-propelling particles that break time-reversal symmetry by orbiting or spinning, leading to intriguing behaviors. Here, we examined the dynamics of CAPs moving in 2D lattices of disk obstacles through active Brownia