Aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD) is a rare central nervous system (CNS) autoimmune disease in adults and children classically characterised by myelitis, optic neuritis and/or area postrema syndrome. This case and the additional recently reported AQP4-NMOSD ...
neuromyelitis optica (NMO), an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord, is caused by the development of an autoantibody directed against AQP-43.Abgent is pleased to offer a highly specific antibody directed against an epitope of rat Aquaporin 4 channel...
产品类型 Antibody 全称 Aquaporin 4 别名 AQP 4, AQP4, aquaporin 4, HMIWC2, MIWC, WCH4 计算分子量 323 aa, 35 kDa 观测分子量 35-37 kDa, 32-34 kDa GenBank蛋白编号 BC022286 基因名称 Aquaporin 4 Gene ID (NCBI) 361 RRID AB_2920230 偶联类型 CoraLite® Plus 647 Fluorescent Dye 最大激...
White matter disease: aquaporin-4 antibody-positive patients may not always fulfil the clinical criteria for neuromyelitis optica.HumansNeuromyelitis OpticaFemaleMaleAquaporin 4Comment on Neurology. 2013 Jun 11;80(24):2210-6.doi:10.1038/nrneurol.2013.111Wood...
82 Eculizumab is a humanized monoclonal antibody that inhibits complement and showed significantly lower risk of relapses in patients with NMOSD compared with placebo.83 Finally rituximab, a CD 20 B cell depleting antibody, prevented relapses in patients with NMOSD AQP-4 positive patients compared ...
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre Brain (2007) There are more references available in the full text version of this article. Cited by (9) Therapeutic Approach to the Management of Pediatric Demyelinating Disease: Multiple Sclerosis and Ac...
There was an inverse relationship between disease amelioration and antibody titer in one NMOSD patient, whereas the antibody titer remained high in the other NMOSD patient, whose clinical manifestations of NMOSDs did not improve despite intensive immunosuppressive treatments. Conclusions These results ...
Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients. J Neuroinflammation. 2012;9:14.PubMedGoogle ScholarCrossref 5. Marignier R, Bernard-Valnet R, Giraudon P, et al; NOMADMUS Study Group. Aquaporin-4 antibody-negative ...
However, such titers are frequently seen in NMOSD [69], where "low titer patients experience the same disease course as medium-titer and high-titer anti-AQP4 antibody pa- tients" [70]. Low titers of AQP4-reactive antibodies could indicate their depletion from the circulation, for example by...
AQP4-IgG seropositive neuromyelitis optica spectrum disorder is an autoimmune disease that is uniquely suited to antibody blocking therapy because it is caused by circulating autoantibodies that initiate cellular pathology by binding to a small, well-defined, cell-surface exposed target, AQP4. Other aut...