In this study, we investigated the relationships between the levels of amyloid-β oligomers, amyloid-β plaques, glial activation and markers related to neurodegeneration in the AppNL-G-F triple mutation mouse line and in a knock-in line homozygous for the common human amyloid precursor protein ...
In this study, we investigated the relationships between the levels of amyloid-β oligomers, amyloid-β plaques, glial activation and markers related to neurodegeneration in the AppNL-G-F triple mutation mouse line and in a knock-in line homozygous for the common human amyloid precursor protein ...
Object exploration was defined as the mouse sniffing or touching the object with the nose while looking at it. Climbing onto the object or chewing was not considered exploration. An experimenter blinded to the mouse condition tested assessed the exploratory activity manually. The amount of time ...
The characterization of three AD mouse models at different disease stages provides an unprecedented view of AD pathology and how this differs from physiological aging. Moreover, our computational strategy to chemically revert AD signatures has shown that NSAID and anti-hypertensive drugs may still have...
(Additional file1: Table S1). Tau seeding material was prepared from each patient sample on different days and verified for seeding capability by testing on mouse primary neurons. Additionally, western blotting and ponceau S staining was used to evaluate the seed purification protocol (Additional ...
Thus, MGnD could exacerbate tau spreading throughout the brain. To determine the role of MGnD on tau propagation, we employed microglia depletion in adeno‐associated virus (AAV)‐mediated tau propagation mouse models.doi:10.1002/alz.040958Kevin Clayton...
insight into the microscale mechanics of aging brain tissue, we measured spatiotemporal changes in the mechanical properties of the hippocampus using high resolution atomic force microscopy (AFM) indentation tests on acute brain slices from young and aged wild-type mice and the APPNL-G-F mouse ...
Alzheimer's diseaseatomic force microscopybrain tissue elasticityhealthy aginghippocampus[This corrects the article DOI: 10.3389/fnagi.2023.1212212.].doi:10.3389/fnagi.2023.1273549Chloe M HallSoufian LasliBianca SerwinskiBoris DjordjevicGraham K Sheridan...
Therefore, utilizing a novel App knock-in mouse model (AppNL-G-F) exhibiting robust A尾 pathology, neuroinflammation and memory impairment, we have explored the relation of A尾 pathology development in the brain with alterations in the peripheral immune compartment. Method Usi...
To address this question, we employed the App(NL-G-F/NL-G-F) mouse, an A beta deposition-bearing mouse without neurofibrillary tangles and neuronal cell death throughout the lifespan and used a progressive-ratio (PR) task to monitor instrumental motivation between the ages of 16 and 39 ...